What illnesses/diseases have been studied with specific regards to a ketogenic diet?

(melinda) #1

as part of the nutrition class I’m teaching (yay!) I’m compiling a ketogenic way of eating quick start guide and faq.

I want to make a long list of the illnesses that are specifically supported as being helped by a ketogenic diet, the illnesses which have scientific evidence that a ketogenic diet COULD help them, and those for which there is anecdotal evidence that keto helps.

Input appreciated! Please provide a link to the study if you have it!

Edit: My list so far, will update. I am STUNNED at the amount of medical information I am getting right now. Holy Shit. Keto is amazing.:

b. Illnesses with scientific medical evidence supporting a ketogenic way of eating:
i. Diabetes

  1. Hundreds of studies available at https://www.ncbi.nlm.nih.gov
  2. https://www.ncbi.nlm.nih.gov/pubmed/23680948
  3. https://www.ncbi.nlm.nih.gov/pubmed/21533091


  1. Hundreds of studies available at https://www.ncbi.nlm.nih.gov

iii. Obesity & Related Diseases

  1. https://www.ncbi.nlm.nih.gov/pubmed/27643725
  2. https://www.ncbi.nlm.nih.gov/pubmed/15148063
  3. https://www.ncbi.nlm.nih.gov/pubmed/27357802
  4. https://www.ncbi.nlm.nih.gov/pubmed/26410589
  5. https://www.ncbi.nlm.nih.gov/pubmed/20395146
  6. (& strength training in women) https://www.ncbi.nlm.nih.gov/pubmed/20196854
  7. (& maintenance) https://www.ncbi.nlm.nih.gov/pubmed/19506567

iv. Childhood Obesity

  1. https://www.ncbi.nlm.nih.gov/pubmed/23155696

v. Heart Failure & Heart/Cardiovascular Health

  1. https://www.ncbi.nlm.nih.gov/pubmed/26819374
  2. https://www.ncbi.nlm.nih.gov/pubmed/25986079
  3. https://www.ncbi.nlm.nih.gov/pubmed/18478178
  4. https://www.ncbi.nlm.nih.gov/pubmed/12097663
  5. https://www.ncbi.nlm.nih.gov/pubmed/17824299

vi. Stroke

  1. https://www.ncbi.nlm.nih.gov/pubmed/25671178
  2. https://www.ncbi.nlm.nih.gov/pubmed/23050642

vii. Polycystic Ovarian Syndrome (PCOS) & Infertility

  1. https://www.ncbi.nlm.nih.gov/pubmed/27510483
  2. https://www.ncbi.nlm.nih.gov/pubmed/23122539
  3. https://www.ncbi.nlm.nih.gov/pubmed/16359551

viii. Hormonal Cancers (including Breast Cancer & Colon Cancer) & Tumors

  1. https://www.ncbi.nlm.nih.gov/pubmed/28244492
  2. https://www.ncbi.nlm.nih.gov/pubmed/27159218
  3. https://www.ncbi.nlm.nih.gov/pubmed/26408720
  4. https://www.ncbi.nlm.nih.gov/pubmed/25773851
  5. https://www.ncbi.nlm.nih.gov/pubmed/21530093
  6. https://www.ncbi.nlm.nih.gov/pubmed/20831808

ix. Parkinson’s Disease

  1. https://www.ncbi.nlm.nih.gov/pubmed/27326359

x. Alzheimer’s Disease

  1. https://www.ncbi.nlm.nih.gov/pubmed/27458340
  2. https://www.ncbi.nlm.nih.gov/pubmed/23131121

xi. Mitochondrial Diseases

  1. https://www.ncbi.nlm.nih.gov/pubmed/26782788
  2. https://www.ncbi.nlm.nih.gov/pubmed/26661201

xii. Autoimmune Disorders and Multiple Sclerosis

  1. https://www.ncbi.nlm.nih.gov/pubmed/27239035
  2. https://www.ncbi.nlm.nih.gov/pubmed/26839705

xiii. Brain Development During Pregnancy

  1. https://www.ncbi.nlm.nih.gov/pubmed/27331005
  2. https://www.ncbi.nlm.nih.gov/pubmed/25642385

xiv. Gout

  1. https://www.ncbi.nlm.nih.gov/pubmed/28249154

xv. Autism Spectrum Disorder, Neurodevelopmental Issues, & Autism Spectrum Disorder Behaviors

  1. https://www.ncbi.nlm.nih.gov/pubmed/28166277
  2. https://www.ncbi.nlm.nih.gov/pubmed/27836684
  3. https://www.ncbi.nlm.nih.gov/pubmed/27594980
  4. https://www.ncbi.nlm.nih.gov/pubmed/27080080
  5. https://www.ncbi.nlm.nih.gov/pubmed/25011527
  6. https://www.ncbi.nlm.nih.gov/pubmed/24399946
  7. https://www.ncbi.nlm.nih.gov/pubmed/23755170
  8. https://www.ncbi.nlm.nih.gov/pubmed/22690843
  9. https://www.ncbi.nlm.nih.gov/pubmed/12693778

xvi. Mitochondrial Myopathy

  1. https://www.ncbi.nlm.nih.gov/pubmed/27647878

xvii. Cluster Headaches & Migraines

  1. https://www.ncbi.nlm.nih.gov/pubmed/25156013

xviii. inflammatory dermatologic disease

  1. https://www.ncbi.nlm.nih.gov/pubmed/28043175

xix. Kabuki syndrome

  1. https://www.ncbi.nlm.nih.gov/pubmed/27999180

xx. Endotoxemia

  1. https://www.ncbi.nlm.nih.gov/pubmed/27117864

xxi. Mitochondrial Adaptations

  1. https://www.ncbi.nlm.nih.gov/pubmed/27877138

xxii. Neurodegenerative Diseases / Neurological Issues

  1. https://www.ncbi.nlm.nih.gov/pubmed/22509165
  2. https://www.ncbi.nlm.nih.gov/pubmed/27651266
  3. https://www.ncbi.nlm.nih.gov/pubmed/20204773
  4. https://www.ncbi.nlm.nih.gov/pubmed/16940764

xxiii. Mental Health Disorders including Schizophrenia & Bipolar Disorder

  1. https://www.ncbi.nlm.nih.gov/pubmed/26547882
  2. https://www.ncbi.nlm.nih.gov/pubmed/15601609
  3. https://www.ncbi.nlm.nih.gov/pubmed/18208598
  4. https://www.ncbi.nlm.nih.gov/pubmed/23050642
  5. https://www.ncbi.nlm.nih.gov/pubmed/19245705
  6. https://www.ncbi.nlm.nih.gov/pubmed/11918434

xxiv. Congnitive Function in the Elderly

  1. https://www.ncbi.nlm.nih.gov/pubmed/27568199
  2. https://www.ncbi.nlm.nih.gov/pubmed/24713058

xxv. Lennox-Gastaut syndrome

  1. https://www.ncbi.nlm.nih.gov/pubmed/27052529

xxvi. Huntington Disease

  1. https://www.ncbi.nlm.nih.gov/pubmed/27031732
  2. https://www.ncbi.nlm.nih.gov/pubmed/21501628

xxvii. ADHD

  1. https://www.ncbi.nlm.nih.gov/pubmed/26773515

xxviii. Psoriasis

  1. https://www.ncbi.nlm.nih.gov/pubmed/2655989

xxix. Fatty Liver Disease & Insulin Resistance

  1. https://www.ncbi.nlm.nih.gov/pubmed/26556368
  2. https://www.ncbi.nlm.nih.gov/pubmed/24247928
  3. https://www.ncbi.nlm.nih.gov/pubmed/24247485

xxx. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  1. https://www.ncbi.nlm.nih.gov/pubmed/26315446

xxxi. Traumatic Brain Injury & Spinal Cord Injuries

  1. https://www.ncbi.nlm.nih.gov/pubmed/24721741
  2. https://www.ncbi.nlm.nih.gov/pubmed/24223849
  3. https://www.ncbi.nlm.nih.gov/pubmed/19408168
  4. https://www.ncbi.nlm.nih.gov/pubmed/19049605

xxxii. Chronic Pain

  1. https://www.ncbi.nlm.nih.gov/pubmed/24930805
  2. https://www.ncbi.nlm.nih.gov/pubmed/23680946
  3. https://www.ncbi.nlm.nih.gov/pubmed/20041135

xxxiii. Glycogen Storage Disease Type III & Cardiomyopathy

  1. https://www.ncbi.nlm.nih.gov/pubmed/25308556

xxxiv. The nervous system and metabolic dysregulation

  1. https://www.ncbi.nlm.nih.gov/pubmed/21612461
  2. https://www.ncbi.nlm.nih.gov/pubmed/22470316

xxxv. Glaucoma & Optic Nerve Disorders

  1. https://www.ncbi.nlm.nih.gov/pubmed/24600621

xxxvi. General Quality of Life in those with Chronic Diseases

  1. https://www.ncbi.nlm.nih.gov/pubmed/28038385
  2. https://www.ncbi.nlm.nih.gov/pubmed/23801097

Chronic fatigue
Keto and Parkinson's Disease
Help! Stroke information

My guess is that epilepsy is the most studied for keto as a therapeutic tool.

(melinda) #3

Four hours of research and I have the above list!! This isn’t a comprehensive list of all the articles, there were 2000+ that mentioned “ketogenic”

(Todd Allen) #4

And the other way to phrase this: What are the diseases caused by following the US dietary guidelines?

(melinda) #5

So. Freaking. True.

(Anders ) #6

I can only speak for myself though, but I have a condition called ulcerative colitis, a chronic inflammation of the large intestine, and even on meds I go to the bathroom 4-6 times a day.

After around 7-8 weeks of keto I started improving, and I am now rarely going more than once a day. I also have a chronic inflammation in the lining of my mouth that has decreased drastically. Haven’t found any science on that though, but keto’s decreased inflammatory properties are at play, I’m certain


I was expecting to see Pompe on the list, sounds like they’d benefit from it - at first glance anyways.

(Michael Wallace Ellwood) #8

I’d be interested to know if arthritis (osteo- or rheumatoid-) has featured in any relevant study.

(melinda) #9

I did see one on arthritis! rheumatoid I think.

(melinda) #10

Oh yeah, there’s lots of articles on keto’s anti-inflammatory properties.

(MakinBacon) #11

My mom has RA, and she was told by her dr to go on a gluten free diet. She does not have celiac disease. There was minimal if any improvement. So she took it a step further and went grain free, and saw improvement. She isn’t doing keto yet, but is very interested in trying it out.

(Jennifer) #12

Dang, what a list. Anything on sleep apnea?

(melinda) #13

I didn’t see anything specifically, but weight loss improved mine!

(MakinBacon) #14

I wish! I have sleep apnea, and my dr said losing weight will improve it, but not eliminate it. I’ve been unable to breathe through my nose at night going all the way back to childhood, even when I was super skinny.

(Jennifer) #15

My brother is overweight and has sleep apnea. Was hoping to arm myself with as much data as possible to try and convince him to try keto.

(melinda) #16

This one mentions sleep apnea!

(melinda) #17

And here’s an anecdotal:

(melinda) #18

(Cathy) #19

WOW!!! Thank you for sharing this list. I am copying it for further examination and sharing with people in my real life!


I’ve been thinking about the rise over the past few decades of autism, and the lack of clear explanations from medical science. I wonder how much low-fat habits of moms accidentally affect pre-natal diets and in turn affect brain development.

(saw a bunch of autism articles linked above…)

“Maternal intake of linoleic acid was significantly inversely associated with ASD risk in offspring, corresponding to a 34% reduction in risk in the highest versus lowest quartiles of intake. Mothers in the lowest 5% of ω-3 fatty acid intake had a significant increase in offspring ASD risk as compared with the remaining distribution”