For anyone else interested/concerned about this, Amy Berger seems to be the go-to person these days. She notes that “50% of people with AD are not E4 carriers.” But she also says exogenous ketones, which have shown to be very helpful to many Alzheimer’s patients, aren’t as effective on E-4s, and in some cases don’t work at all.
What’s interesting is that E-4 is considered the oldest of the three APOE genotypes. It’s called the “hunter-gatherer” genotype, which is “poorly suited for the modern diet’s evolutionarily discordant amount of refined carbohydrates.”
There are some otherwise pro-low carb doctors (Dr. Steven Gundry) out there who advise E-4s to cut out animal fats, but I wonder if the opposite is true. Maybe we E-4s need MORE fat, since our brains are resistant to the effects of ketones?
Insulin resistance and reduced brain glucose metabolism in the aetiology of Alzheimer’s disease
Amy L. Berger
Gundry has an in-depth video about lowering small dense LDL, and is very much against cheese, butter and other animal fats for E-4s. Bye-bye bacon nectar… (At least he encourages eating tons of olive oil and fish oil!)
If I’m missing something, please help – I’m trying to get up to speed on this.