Heart Labs

[DebRox]

I found detailed heart labs I had performed back in 2011.

Upon reviewing the paperwork it is revealed that I have ApoE Genotype 2/3. The explanation is provided

“This patient has the ApoE genotype E2/E3. Over 95% of individuals with type III hyperlipoprotienemia are homozygous for the E2 allele. Only rarely does this disorder occur with the heterozygous genotype E2/E3; results must be interpreted within the context of the appropriate clinical setting and rarely with other laboratory data. E2 carriers have a slightly lower risk of coronary heart disease (CHD) compared to individuals with E3/E3 genotype”

Does this mean I am not a good candidate for Keto?

I have been ketoing for about 10 weeks now. I do find my heart racing a little more than normal, especially at night which I have been attributing to dehydration.

I am enjoying the increase in energy I have from Keto and better sleep. I really do not understand what the ApoE genotype mean. Does anyone know?

[J_A-M]

I do find my heart racing a little more than normal, especially at night which I have been attributing to dehydration

What are you doing for electrolytes?

E2 carriers have a slightly lower risk of coronary heart disease (CHD) compared to individuals with E3/E3 genotype”

I’m confused. You said you were E2/E3? This says E2 has lower CHD risk so, isn’t that good? You have E2.

[Capnbob]

This is a whole thread on APoE4 (the most dangerous one apparently). This entry mentions the 2 and 3 variants which seem much better (See below). Having the 4 variant makes it even more essential to do keto to mitigate the inherent risks of CVD/AD/etc. It doesn’t look like 2/3 has any negative connotations vs. keto. KCKO and don’t worry about your genes?

Is keto less effective in people with APOE-4 genotype?

I just got my 23AndMe results and ran them through Promethease. I went to Promethease originally because while 23 said I didn’t have the ApoE4 gene, they didn’t say what I had. Promethease says I’m ApoE3 in both places, which is considered “neutral risk”. E4 E4 is considered risk for stroke, Alzheimer’s, etc. E3 E3 is neutral and E2 E2 is considered good (they don’t use the term “protective”). Are there other things to look for?

[DebRox]

Thank you for the responses.

Upon reviewing the results, the 2/3 result is highlighted in yellow which means caution. The doctor wrote down that 2 was a variant. Not really sure what that means.

Her real worry was the KIF6 Genotype which is “Arg/Arg” which is rare and means that I have a 55% increase for chronic heart disease.

Well I think I will go for bloodwork soon to see how things are.