Looking through some science around fat fasts and autophagy I came across this:
A lot to take in there, but it seems that alcohol inhibits mTOR and promotes autophagy, particularly fatty liver lipids and damaged mitochondria. It seems a sort of built in mechanism to repair the liver when it is damaged. I am not recommending over-consuming alcohol, but it seems that if the goal is autophagy then some booze help.
A couple callouts:
Recent studies have indicated that alcohol may activate autophagy as a protective mechanism against alcoholic liver injury by selectively removing damaged mitochondria and hepatic lipid droplets. Alcohol-induced autophagy requires alcohol metabolism and production of ROS. In addition, alcohol may also induce autophagy by impairing the Akt-mTOR pathway. Alcohol-induced proteasome inhibition and ER stress, as well as AMPK- and mTOR-independent pathways, could also be involved in alcohol-induced autophagy in the liver. Modulating autophagy could provide novel therapeutic approaches for treating ALD.
These findings support a pro-survival role of autophagy in maintaining protein, lipid and organelle quality control by eliminating damaged proteins and organelles as well as excessive lipid droplets in the liver during stress.
How is it possible that alcoholism induces liver injury and even death due to alcoholic liver cirrhosis if alcohol-induced autophagy plays a protective role? Increasing evidence now support the notion that autophagy and apoptosis mutually regulate each other 86. Autophagy not only provides nutrients for the cell survival during starvation but also selectively removes damaged organelles including damaged mitochondria 87.