Ozempic/Trulicity method of action

science
(Susan) #1

I’ve been taking Trulicity for over a year. My physician says it’s functionally identical to Ozempic. I don’t know why I waited so long, but now I’m looking into it. I was told that it decreased how quickly food left the stomach, thus making you feel fuller and making your food get to your blood stream in a more gradual way. Now I hear that it increases insulin and decreases glucagon. Isn’t that the exact opposite of how you stay in ketosis? Isn’t it the opposite of what fasting does (IF or regular).

Trulicity’s been minimally successful for me but when I go off, I start gaining again. Most days (>85% I’m very strict keto, < 20g). Some days my husband bakes bread. He’s healthy but went on keto with me to be supportive, lost 20 lbs quickly and was at his early adult weight and stopped.

(Geoffrey) #2

I don’t know anything about those drugs other that what I’ve read about the side effects but one thing is for sure. If you are going to use them then you’ll have to use them forever. It’s no different than a diet. Once you stop doing it then the weight will come back and quite often you will gain even more than before.
I saw that happen to my daughter and a few others I know that were using it for weight loss. I think I’ve got my daughter convinced now that a change of lifestyle is the only thing that will and has ever worked.

(Susan) #3

@Geezy56. Thanks for the warning. I think it came to late for me. We’ll see what happens when/if I stop. I appreciate your quick response.

(Bob M) #6

Here’s a study on one of the drugs:

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I have been testing some things that supposedly help to increase the amount of GLP-1 (a hormone that can cause reduced hunger). What I’m doing does seem to work.

Semaglutide seems to work by increasing receptors to GLP-1 rather than increasing GLP-1 itself. There are other “benefits” too:

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(Betsy) #7

What are you testing that increases the amount of GLP-1?

(Susan) #9

@ctviggen. Well, I did say show me the science!! Thanks. This was helpful.

(Betsy) #10

I know there are supplements that enhance GLP-1, such as berberine, so I was asking him to see if he knew of any others.

(Betsy) #12

Is okay :slightly_smiling_face:

#13

Sorry, but there’s no truth to that at all. Ozempic / Semaglutide makes you Insulin sensitive right out of the gate, it lets you eat less, not fight an uphill battle of trying to mobilize fat out of storage for many times months while you’re doing damage control, lowering chronically high Insulin load, regaining Insulin sensitivity, and therefor losing bodyfat. While you’re doing all of that you’re by default lowering the Insulin load from chronically elevated, to up and gone, the way it’s supposed to work, Testosterone and Estrogens come back into their correct range as much as they can from diet alone, Stress hormones decrease, you’re still gaining the overwhelming majority of positive effects.

Diet being right for long term success is a given regardless of any supplements or Peptides you take to assist you, but that’s always the case. Saying you require the peptides forever because you used them to help the process along is incorrect. Everybody that takes them is (supposed) to also be eating a correct diet. People that use them to cheat while still eating crap all the time is people just being lazy, that’s not a failing of the drugs or peptides, it’s a failing of the person using them, doesn’t change that somebody doing it right has no reason or requirement to stay on them for life if they don’t want to be. You don’t just get fat again, you have to intentionally repeat the same failure.

#14

Except that’s not right, see my response to that statement below. Can’t blame a peptide for people going back anymore than the people that same the same exact thing about people eating Keto and going back to SAD.

#15

It does, it also makes you more Insulin sensitive, so you release enough to do the job in the first place, vs an Insulin resistant person that lets it get insanely high, and then overreacts over the course of hours.

On the gaining, when you go off, how much? Are you tracking your intake? How much is still on you that you’re trying to get off? I can tell you the hype is real with Semaglutide, my fasting numbers were never as good as they are when off it, my blood sugar can be back at baseline in under 2hrs even after a real good beating when that happens, and controls my uncontrollable appetite.

(KM) #16

Not sure how we’re not saying the same thing. I’m not blaming a peptide for people going back, I’m saying if you stop taking the drug (or eating the diet) and go back to your former status quo, you can’t expect the results you got while partaking to be permanent, your body changes back too. Are you saying you can stop taking the semaglutide and retain the insulin sensitivity?

(You've tried everything else; why not try bacon?) #17

In a lecture I watched, a while ago, Andreas Eenfeldt joked, “Keto is like showering. If you stop showering, you get dirty again. Life is so unfair like that.”

(You've tried everything else; why not try bacon?) #18

Since the whole point of the drug is to be able to eat as one wishes, without changing the diet, that is simply to be expected. They already know that people who stop taking the drugs regain the weight, plus some. Also, Prof. Bikman is concerned that a lot of the weight lost is not just fat but muscle, which is hard to regain after stopping the drug, apparently. Also, the slowing of peristalsis in the intestines appears to be permanent, causing further problems.

(Bob M) #19

Both inulin (a long chain fiber) and allulose. Trying 1-2 tsp of inulin and 2 tsp allulose at lunch. Inulin alone or maybe this combination can get tricky. Too much inulin, and I get some digestive upset.

Edit: This does seem to work, although (1) it takes hours after eating for me to get a lower appetite; and (2) it’s inconsistent. Some days, I go home not hungry and have little for dinner. Most days, I go home not hungry, but end up eating a normal dinner. I can’t tell which days will be which.

Inulin possibly changes the gut biome so that you reduce bacteria that lead to less GLP-1 being released. Allulose supposedly helps release more GLP-1, along with causing insulin sensitivity.

Here’s the allulose one:

You can find the paper too.

The inulin was from Nick Norwitz:

https://www.youtube.com/watch?v=hiCxpHDAlbs

Of course, with inulin, it might (like ozempic) delay gastric emptying just because it’s a fiber.

I haven’t been able to build up to 10-20 grams of inulin per day, which some studies use. Barely get to 6 grams a day most days. Fiber and I tend not to get along, so higher doses affect me.

(Betsy) #20

Thank you, very interesting.

(Susan) #21

@ctviggen
Could you put the allulose and maybe even the inulin in food? I was thinking I could use the allulose to sweeten a keto mug cake and perhaps decrease the coconut flour because I’m also putting in inulin? I’ve got allulose, but haven’t ever tried inulin. I do decrease the coconut flour by adding some ground psyllium seed.

(Geoffrey) #22

So are you saying that those drugs somehow fix what’s wrong with your body that causes obesity in the first place?
That would be interesting and something to see. I have known several people who have gone this route and they have all failed because the majority of everyone that goes on those drugs are wanting an easy way out. The magic pill.
If they could and would eat right (subjective I know) they would feel the need to take the drugs in the first place.
At least that’s been my experience.

(Susan) #23

@ctviggen

This guy is great. I listened to a number of his videos and he really goes into the science in a very good way. He’s also really positive about allulose. I watched a different guy that is keto adapted, had fasted for 16 hours and then had 50 g of allulose (very sweet) and his blood sugar and blood ketone readings didn’t budge at 30, 60 and 120 minutes.

Are you taking pepto bismol like Nick also suggested in the same video? He cites a study that says also it increases the natural release of GLP-1 (like allulose and inulin).

(Alec) #24

Susan
If you have weight to lose, can I heartily recommend going carnivore… I was keto and the weight loss was slow/non-existent. I went carni and suddenly the magic started… down nearly 100lbs over 12 months.

Of course we are all different, so your results may be different, but when I started, I thought carni was just for the crazies…. I kinda fell into it by noticing that I lost more weight when I was 100% carni, and I was eating NO plants at all. I then just continued doing it, and it became my normal with (frankly) spectacular results.

I am now a 100% believer that if anyone has stubborn weight to lose, carnivore is the way.

Take care and best of luck!
Cheers
Alec