It is commonly believed that the brain must have some glucose for certain of its cells, but in a recent lecture, Benjamin Bikman stated that he’s been unable to find any scientific evidence to confirm this.
Dr. Phinney often recounts the story of a study performed by friends of his, on the effects of starvation ketosis. One day, they infused insulin into the participants and drove their blood sugar down to levels of glucose normally associated with coma and death. They were perfectly fine. (Naturally, treating human subjects like this today would be a serious violation of ethical rules.) As Dr. Phinney says, “The only people feeling lightheaded and having palpitations were the ones in the white coats.”
I’m sure there is a glucose level that really is too low, even for people who are fat-adapted—after all, our red blood cells can’t survive without glucose, and there may be other cells in the body, too—but the dangers normally associated with hypoglycemia appear to occur, if they occur at all, at a significantly lower level of serum glucose.