The headlines:
The VAST majority of this is in mice. Not humans.
The study, in mice:
https://www.nature.com/articles/s43587-026-01169-0
The garbage just keeps going:
From here:
I eat as much protein as I want to, and my last HS-CRP (high sensitivity c-reactive protein) was 0.5, and the previous one was 0.2. That’s low. I have other blood inflammatory markers that are also very low. While eating as much protein as I want to eat.
It would be interesting to see a meta-analysis of all these studies done in mice and how many replicate in humans. In general, I’m not even sure they replicate in other mice.
Indeed, Bob. If we are to note or look for causes of inflammation, obesity, etc., then pointing the finger at protein is junk science, and hilariously so. (In my opinion.)
That last one - “Cell Press Blue”… ‘Cell Press’ and the like are often destinations for many papers that aren’t fit for other places.
Cell Press Blue: “Discounted Article Publishing Charge (APC): Free. This discount is valid for articles submitted by 30 December 2026. Full APC without discount: USD 7,000 (excluding taxes).”
It’s ‘pay-to-publish’ but it’s free until the end of the year. 
The original ‘Cell’ magazine started 50+ years ago - part of MIT Press in Massachusetts. ‘Cell Press’ was an attempt to capitalize on the name similarity. I’m also not saying there necessarily never was anything good about it… Who knows?
Now, all the above are owned by Elsevier, a big publishing company, and everything is mixed up and (IMO) heavily bastardized.
So much of it all - both the good and the bad - is related to money. Anybody, saying anything, can be “published,” now. If I’m wanting some grant money, me having been ‘published’ means my chances of getting the money are increased.
I’m certainly viewing it with a jaundiced eye, here, but the entire spectrum of ‘peer review’ and things being published because of money, or for money, rather than their true merit - has become a big mess.
Let’s suppose I am a naive one and believe the articles. My take is that we shouldn’t be sedentary 
I am all for that, it has so many benefits.
(Yeah, I am so interested in the lifespan of flies with reduced protein intake…)
I don’t like overeating protein though, it’s wasteful and beyond some point unhealthy. Oh and I stay fat. But that’s me.
Of course, my definition of overeating protein is probably vastly different from the ones who are in the “less protein is better” camp but I don’t even know about their idea, skimmed the articles but stayed clueless.
And if I could ever undereat protein (not true), I surely would stay fat. I am starving below a decent amount and even massive overeating of calories can’t help with that. I trust my body to know what it needs.
Oh and I wouldn’t want to make my life longer on a super miserable, impossible low-protein diet… But I probably would live much shorter. Bad deal.
