Is there a biochemist in the house?


(Ian Keith) #1

currently in my biochemistry class the professor knows keto is good for losing weight but firmly believes that the oxidation of LDL from creating ketones will cause atherosclerosis, and glutothione will not be able to keep up, because it requires carbohydrates.

How do i strengthen my argument?

iv’e found studies but without mechanisms of actions they arn’t much help.


(Carl Keller) #2

This thread needs an @atomicspacebunny.


(Bunny) #3

True, ketones or a high fat diet[1] might or could cause glutathione depletion (at least in rats?) in theory as discussed by Chris Masterjohn PhD but that is why we have bone broth and other foods[2] to make sure that does not happen? We are always going to get some carbohydrates from somewhere; just eliminating the highly processed carbohydrates and refined sugars is key, not even requiring a high end ketogenic diet as you see here on the forum?

As Dr. Ben Lynch phrases it “…glutathione is the MASTER anti-oxidant of all anti-oxidants, without it all attempts at methylation are futile…” in other words any anti-oxidant you put your body simply will not work (can actually do the opposite and do severe damage) if glutathione and selenium are not present or insufficient? Nutrigenomic polymorphism are not destiny if one understands where the mothership is located?

Deficiencies in micronutrients on any kind of diet will cause breaks, rips and tears in the chromosomes! E.g. organic sulfur depleted from the ground soil and replaced by chemical fertilizers which in turn creates sulfur deficiencies in the human body, sulfur is the precursor to glutathione! Another type of deficiency; not enough exogenous cholesterol in the diet contributing to the formation of all cancers to keep the body alive while trying not to kill the host?

Footnotes:

[1] In that study (6), high-fat diets depleted glutathione and impaired insulin sensitivity and glucose tolerance …More

[2] Overview on working hypothesis:

  1. Glycine (searchable database of the methionine/glycine balance of almost 4000 foods)
  2. Cysteine (Top 10 Foods Highest in Cysteine)
  3. Glutathione & Glutathione synthetase deficiency (10 Natural Ways to Increase Your Glutathione Levels )
  4. Catalase (Vegetable & Fruit Sources of Catalase) Onions (highest concentrations) &; Wheat Grass

Deficiencies could impair weight loss on a high fat diet or low fat diet and contribute to diabetes and possibly liver damage? …More


Introduction, superfoods and why Keto makes you more efficient?
Hair loss and new straight texture
Bone broth benefits. Where is the research?
(Betsy) #4

https://www.ncbi.nlm.nih.gov/pubmed/26661201

Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity.`

superoxide dismutase, phfew

Cerebral metabolism of ketones after traumatic brain injury (TBI) improves neuropathology and behavior in an age-dependent manner. Neuroprotection is attributed to improved cellular energetics, although other properties contribute to the beneficial effects. Oxidative stress is responsible for mitochondrial dysfunction after TBI. Ketones decrease oxidative stress, increase antioxidants and scavenge free radicals. It is hypothesized that ketogenic diet (KD) will decrease post-TBI oxidative stress and improve mitochondria. Postnatal day 35 (PND35) male rats were given sham or controlled cortical impact (CCI) injury and placed on standard (STD) or KD. Ipsilateral cortex homogenates and mitochondria were assayed for markers of oxidative stress, antioxidant expression and mitochondrial function. Oxidative stress was significantly increased at 6 and 24 h post-injury and attenuated by KD while inducing protein expression of antioxidants, NAD§H dehydrogenase quinone 1 (NQO1) and superoxide dismutase (SOD1/2). Complex I activity was inhibited in STD and KD groups at 6 h and normalized by 24 h. KD significantly improved Complex II-III activity that was reduced in STD at 6 h. Activity remained reduced at 24 h in STD and unchanged in KD animals. These results strongly suggest that ketones improve post-TBI cerebral metabolism by providing alternative substrates and through antioxidant properties, preventing oxidative stress-mediated mitochondrial dysfunction.


(less is more, more or less) #5

Just like Batman, can we project a silhouetted spotlight under a cloudy night to beckon our trusty science-hero?


(Consensus is Politics) #6

Ok guys, settle down.

Dibs.

Ok, there, I said it. Now, let’s continue on with the science :sunglasses:.

Keto Vitae!


(Consensus is Politics) #7

Dr Keys beleived a high fat diet caused heart disease. Then he went on to ‘prove’ it, instead of testing it of course, he already beleived it so it must be true.

You don’t need to prove that to him. Ask him to show you the science. Start there.


(The amazing autoimmune 🦄) #8

Thank you for your hard work in providing great science info and links for the forum. I always look for your posts as I learn something very time.


(Consensus is Politics) #9

Ditto


(The amazing autoimmune 🦄) #10

:joy::rofl::joy::rofl::joy:


(Ian Keith) #11

thank you that was exactly what I needed.