Margot, I haven’t read any books about autophagy. I just googled "books about autophagy’ and there are a fair number of them, mostly written in the last 10 years. I’ve looked at studies and experiments, and online discussions about the subject. We’re really in our infancy as far as understanding it, and if there is a “consensus” view it will likely be changing as time goes forward.
In mice - creatures that have a much faster metabolism, and that will usually be dead after fasting for 3 or 4 days, autophagy is still increasing in some tissues at 48 hours of fasting. We know that autophagy is quite sensitive to insulin levels, and the studies on fasting humans I’ve seen show a decline in insulin (good for autophagy) into the 4th or 5th day of fasting, and then usually a slight rebound. So, my opinion is that getting to 4 or 5 full days of fasting is a good thing for us people.
There are also benefits that come to us during the ‘refeeding’ period after a fast, so in the end it may be that 2 fasts of 5 days are actually better for us than 1 fast of 10 days - I just do not know.
Projecting from the mice - not saying we should fast halfway to the death point.
I wish we knew when autophagy peaked in all our various tissues.
There are other things that affect autophagy, even our own individual genetics. In many of our tissues - especially the ‘non-mitotic’ ones where the cells cannot divide and multiply to dilute the consequences of some cells getting old, damaged, faulty, etc., autophagy is always going on (or supposed to be) at a low, basal level. Nerve tissue is this way, and problems with the “cleaning out” that autophagy does leads to build-ups of the damaged amino acid components like amyloid plaques and misfolded tau proteins - heavily implicated in Alzheimer’s Disease.
Since we really do not yet know what is the generalized most efficient use of autophagy for humans, and are even less on a sure footing for a given indivdual, I would err on the long side, to be safe, versus the short side.
If one is pretty lean, then fasting for multiple days will often be a real problem - and I don’t know what I will do if I ever get to that physical state.