I think itās quite well done, good and timely. Such things tend to be heavy going, as far as reading, and thereās plenty of that in the study, but overall I think itās sound and well-presented.
And maybe I was just in the mood to read something todayā¦
The mouse/human human correlation is addressed. I think thereās a lot of interesting stuff in it.
"our findings uncover its (intermittent fastingās) previously overlooked inhibitory effects on tissue regeneration in the skin."
This as many people fast for autophagy, and getting rid of loose/excess skin.
āThe beneficial effects of intermittent fasting on body health are believed to stem from the periodic switching of metabolic fuel sources, which help optimize cellular energy utilization and induce adaptive cellular stress response. This response enhances the expression of antioxidant defense and repair mechanisms, inhibits protein synthesis, and reduces cellular inflammation.ā
Obviously, a ketogenic diet already involves metabolic fuel sources. Itās interesting to think about the trade-offs, if any. Iād be interested to see the same study on really long fasts, versus intermittent ones.
They do say that āMetabolic switching to fatty acid oxidation induces hair follicle stem cell apoptosis and inhibits hair growth in humans.ā But people on a ketogenic diet are already running on fatty acids for the most part, and obviously they donāt all have hair loss, so itās a variable thing, to begin with, in humans.
"Importantly, we show that enhancing HFSCsā antioxidant ability through the external supply of antioxidants can significantly alleviate the inhibitory effect of intermittent fasting on hair follicle regeneration, offering a promising strategy for counteracting its impact on hair growth in humans."
And also: āEnhancing the antioxidant capacity of HFSCs, either pharmacologically or genetically, effectively prevents stem cell death and mitigates regeneration defects.ā
So, for anybody concerned about hair loss, here, one may be protected from it by oneās own genetics, or by adding antioxidants - in the study it was the application of antioxidant vitamin E to the skin.