I know there are a number of Apo E4 threads on this forum but all I found are pretty old and, as we all know, science and opinions change with time. Also, I have some specific questions I’d like to ask the community about my particular situation so, please, don’t hate me for creating a new thread on this topic
Many of you have responded to a couple of my previous threads found HERE and HERE and it’s been immensely helpful - Thank you! Now that I have some new info, I’m turning, once again, to you incredible people for your thoughts and guidance.
I just learned, yesterday, that I’m Apo E3/E4 (heterozygous) from my cardiologist. As a result, he’s concerned about my current Apo B number of 144 and my LDL of 210… Even though my Calcium CT score was 0 and my fasting insulin is currently 2.31.
These are my current numbers for quick reference… They’re also in my other linked posts but let’s make this easy.
Total Cholesterol: 298
Fasting Insulin: 2.31
After doing some research, I read that (no news to anyone here, I know) saturated fats aren’t good for folks with this genotype… It leads to increased LDL cholesterol which, again, according to what I read, is bad for long-term cognitive function and risk of atherosclerosis in this case. Mainly because this genotype causes more absorption of sat fats than one would otherwise absorb.
However, I’ve also read, elsewhere, that a ketogenic diet, by contrast, HELPS with cognitive function in people actively living with AD and/or dementia… So I don’t understand stand how both of these claims can be true at the same time. Or if I’m missing a factor somewhere in the equation.
So, my question for the community is, for someone like myself that’s Apo E4 heterozygous, do you feel it’s wise to stay the course on standard keto? Or is it a better idea to cut back on saturated fats and lean more into monounsaturated fats, as many publications on the matter suggest?
Bottom line… I prefer animal protein over fish all day, every day and my wife doesn’t eat fish so it makes it hard to incorporate. Also, I REALLY don’t want to give up cheese!!
Thank you all, in advance!