Purpose of Experiment
To attempt to lower my A1C from 5.9 mmol/L to 5.4 mmol/L and then also, in accordance with this video https://www.youtube.com/watch?v=NUY_SDhxf4k by Dr. Paul Mason, to lower my sd-LDL by a factor of approximately 3. Also wishing to improve insulin resistance and promote autophagy for removing superfluous skin attained from losing 55 pounds in the previous 18 months. Decided to do alternate day fasting by eating T, Th, Sat, Sun and fast M, W, F such that I would get three fasts of between 30 and 40 hours per week.
Had A1C of 10.3 on May 27, 2021. Had 12 years of severe IBS-D. Started implementing fasting and low carb/carnivore to resolve these issues.
Starting Information for Experiment on September 1st, 2022
52y Male. 168 cm (5’ 6”) and 62.6 kg (138 lbs). A1C of 5.9.
|LDL-P||>3500**||nmol/L low < 1000, Moderate 1000-1299, Boderline 1300-1599, High 1600-2000, Very High >2000|
|LDL-C||339||mg/dL Optimal < 100, moderate 100-130, Boderline 130-159, High 160-189, Very High > 189|
|HDL-C||41||mg/dL > 39|
|Trig||147||mg/dL < 150|
|Total Cholesteral||409||mg/dL 100 - 199|
|HDL-P (total)||27.7||micromol/L >= 30.5|
|Small LDL-P||1775||nmol/L <= 527|
|LDL Size||21.5||nm Pattern A 20.6-23.0, Pattern B 19-20.5|
|LP-IR||54||<= 45 to be under 50% population by percentile|
** using the particle size and small LDL, calculations for LDL-P put it most likely at 7728 nmol/L as the average of between 4807 nmol/L and 10650 nmol/L
Fasted 12 of 30 days, ate 18 days at an average caloric intake of 3315 cal on eating days giving 1989 cal as average daily intake for the month. Starting weight was 138 lbs, end of month weight was 131 lbs. I generally ate TRE between 1 pm and 9 pm. As an example of what I ate, on Sept 29th I ate 3687.5 calories consisting of 262.5 g of protein, 286.3 g of fat and 15.2 g of net carbs. This came from the following: 2 oz beef liver, 3 oz veal thymus, 4 oz beef heart, 2 oz snails, 5 oz salmon, 2 oz chicken liver, 5 oz pork belly, 2 eggs, 6 oz Jarlsberg cheese, 13 oz beef ribeye and 2 oz 100% dark chocolate.
Fasted 13 of 31 days, ate 18 days at an average caloric intake of 3748 cal or a daily average intake for the month of 2176 calories. Starting weight was 131 lbs ending weight was 126 lbs. I generally ate TRE between 11 am and 9 pm. As an example of what I ate, on Oct 29th I ate 4086 calories consisting of 351.3 g of protein, 292.2 g of fat and 12.9 g of net carbs. This came from the following: 1 oz beef liver, 3 oz veal thymus, 6 oz beef heart, 2 oz sheep testicles, 1 oz bone marrow, 2 oz sheep spleen, 1 oz mussels, 2 oz snails, 6 oz salmon, 1.5 oz sardines, 1.5 oz chicken liver, 2 oz pork belly, 10 oz Jarlsberg cheese, 16 oz beef ribeye.
Fasted 13 of 30 days, ate 17 days at an average caloric intake of 4217 cal or a daily average intake for the month of 2389 calories. Starting weight was 126 lbs ending weight was 129 lbs. I generally ate TRE between 9 am and 9 pm. As an example of what I ate on my largest ingestion day, was on Nov 26th I ate 5483 calories consisting of 368.6 g of protein, 432.8 g of fat and 28.5 g of net carbs. This came from the following: 1 oz beef liver, 3 oz veal thymus, 6 oz beef heart, 2 oz bone marrow, 1 oz mussels, 3 oz snails, 1 oz chicken liver, 5.75 oz pork belly, 10 oz Jarlsberg cheese, 4 eggs, 11 oz beef ribeye, 11 oz beef sirloin and 5.25 oz 100% dark chocolate.
I ate daily from Dec 1st until Dec 4th at around 4000 cal and took a second round of blood tests on the morning of Dec 5. My weight has levelled off at 131 lbs. Here are the results
59.4 kg (131 lbs). A1C of 5.5.
NMR-Lipoprofile on Dec 5, 2022
|LDL-P||2800||nmol/L low < 1000, Moderate 1000-1299, Boderline 1300-1599, High 1600-2000, Very High >2000|
|LDL-C||328||mg/dL Optimal < 100, moderate 100-130, Boderline 130-159, High 160-189, Very High > 189|
|HDL-C||79||mg/dL > 39|
|Trig||150||mg/dL < 150|
|Total Cholesteral||436||mg/dL 100 - 199|
|HDL-P (total)||43.2||micromol/L >= 30.5|
|Small LDL-P||500||nmol/L <= 527|
|LDL Size||22.1||nm Pattern A 20.6-23.0, Pattern B 19-20.5|
|LP-IR||25||<= 27 to be LOW|
My HDL doubled in content and greatly increased in number. While my LDL-C remained almost unchanged, my LDL particle numbers dropped significantly, and probably by a factor of 3 based on previous calculations. In addition, the sd-LDL-P more than reduced by a factor of three. This is a tremendous improvement along with the corresponding A1C drop of 0.4. This matches the expectations almost exactly and provided a new calculation for lipid insulin resistance at under 25 or in the LOW category. My doctor was ecstatic and noted that I am strongly pattern A LDL and he considers my CVD risk to be very low despite the extremely high LDL. If not for my high trigs from diabetes I might have qualified as a Lean Mass Hyper-Responder ala Dave Feldman.
I also got the following other blood tests done at the same time as the NMR. A standard lipid profile as well as vitamin B1, B2, B9 and 25Hydroxy, insulin, C-peptide, zinc, iron, TIBC, Transferrin Saturation, Ceruloplasmin, HS-CRP and ESR which were all within the normal range provided by the lab.