Thanks for the additional information on Neu5GC. I’m 67 and I ate a ton of roast beef and hamburger from childhood until around 5 years ago.
As far as cheese, I have Parmigiano Reggiano and Gruyère in the fridge. Dr Guidry says the same as you mentioned about bacteria breaking down Neu5GC. So are those two cheeses ok ?
The Gruyère is aged 12 months and the Parmigiano Reggiano is aged 24 months if it matters.
Cheeses can still have medium to high levels of Neu5GC - depending on the fermentation process and the probiotics used. So, to tell you the truth, I don’t know how much these two are going to have. I am 62 and a little over a year ago I found I had to stop eating anything with A1 casein in it, and cheese could be quite bad for me. I noticed it most with BPH and having to get up at night to pee. Unfortunately, Americans brought the genetically mutated Holsteins from Europe with them, and so A1 casein is in most American dairy. It is in most European dairy too. So, for me, those cheeses would probably drive me crazy. I am very limited now to the least inflammatory dairy. I use goat cheese a lot like I would cream cheese. I have some Peccarino in the fridge which Costco imports. It is sheep cheese, so has no A1 casein and is probably the lowest among the cheeses in Neu5GC. I enjoy it on my morning eggs. I can get local A2 cow cheese, but it is probably going to have more Neu5GC than the Peccarino, although it is slightly cheaper.
To try to answer your question directly, I personally probably would not buy your cheeses - mostly because they probably have A1 casein, but also now because I try to minimize my exposure to Neu5GC… so here I am eating goat cheese, which is probably somewhat high. I just limit myself to having it once every 2 weeks or so, but it is the only thing available to me that I can tolerate and which is spreadable like cream cheese. My strong suggestion is to next time go for the Peccarino or other sheep cheese for any kind of daily cheese habit.
My personal feeling is that it is much more important for cardiovascular disease to include some soluble fiber with all my meals. That is because the gut biome turns it into short chain fatty acids. The more of these made, the more will get into the arteries. Science has shown that the endothelial cells of the arteries “relax” when burning these fats, BP drops and their junctions are less strained - which seems to relate to less chance of oxLDL particles getting under them and starting the disease plaque process. Having said that, though, you also don’t want there to be inflammation going on in the arteries, so should want to keep down any caused by the presence of Neu5GC. The science here is just not caught up, and is sorely lacking, so I have to go on what little science there is, and the other available evidence. For instance the Acciarolis of Italy(residents of the tiny village of Acciaroli) are perhaps the longest lived population in the world. They are a fishing village. The men regularly eat whole anchovies. They also eat their own raised rabbits and chickens, and little other meat. It is hard to argue with a populatiion with a centenarian population of up to 15% - that is far higher than the rest of the world - perhaps currently the highest in the world. So, I eat wild salmon, wild fish, sardines, wild shrimp, crab and weekly lamb roasted in EVOO. Usually, my only red meat for the week is the roasted lamb. Unfortunately, I don’t have a great source for chicken, but I eat two chicken thighs at a meal typically. I feel like I probably was developing CVD 5 years ago, but if so, I’ve apparently reversed it, and none has been found in my recent thoracic aorta and carotid artery sonograms - so I figure I must be doing something right LOL. I am glad you are taking an interest in it, because you may ultimately save your life by changing your diet. Health is obviously not just about producing ketones. However, I will note here that ketones are one of the least oxidizing fuels you can burn, so I am all in favor of keeping my oxidation levels down. The trick is you want your mitochondria to be oxygenated, but you don’t want the rest of your body to be oxidized in the process… So, I have not only changed what I eat, but also the way I cook. I started cooking primarily with saturated and monounsaturated fats probably 20 years ago, because they are not easily oxidized in the cooking process like seed oils are. No fried foods. I roast at no higher than 300F, etc. You are on the right path Hugh. I feel you are to be commended on your willingness to learn and change accordingly. It may just be life saving.
Can’t find natto locally. I do take 4000 FU nattokinase twice per day though. Also take K2 mk7.
Ah, Nattokinase and K2-mk7 -that’s the right stuff at the heart of Natto. Make sure you take vitamin D with the K2.
In the US, natto is challenging to find locally. I used to order it online from a local state and have it delivered. Now, I make it.
I highly doubt that one type of red meat (and pork is also a red meat) is better or worse based on something like whatever you’re talking about. If it was, we’d see all these carnivores keeling over, as most of them eat beef. I guess I’ll learn when I get my next CAC scan in January, as I eat mainly beef, and near zero grass fed and finished beef. With steaks averaging near $20/pound now for non-grass finished, I’m relegated to eating cheaper beef.
My opinion that eating low carb or keto >>>>>>>>>>>>>>>>>>>>>>>>>> than something in beef, TMAO, or whatever the “evil” de jour is.
Found this on the sciencedirect site
https://www.sciencedirect.com/science/article/pii/S2090123225003534
Woo, that one’s a bit above my pay grade. I couldn’t find any obvious flaws in the study, (doesn’t mean there aren’t any, I got a bit drowned in the biochemistry) other than my usual question about animal research. If the symptom is not caused by the same mechanism which causes it naturally, can we really assume that the intervention which changes it in the experiment is relevant? If I come to you with a headache and you say ‘well, my study shows that decreasing coffee consumption can help a lot’, but it turns out I’ve been hitting my head on the door jamb every morning, cutting out the morning java isn’t going to help me.