SIRT1, Keto, and Autoimmune Disease

autoimmune
hashimotos
thyroid
newbies
sirt1
(Kimberly) #1

I’m posting this in the Newbies section only because I am, indeed a Newb. I’m rounding out 4 weeks of fully embracing the Keto WOE. I’ve seen a few references to SIRT1 in this forum and just need a bit more information. Currently, I’m devouring all the information I can to help me along as I’m embarking on this life change. So, can any of you more experienced and well-informed folks out there help me understand what’s up with with the SIRT1 gene, keto, and how they interact with autoimmune disease (particularly thyroid related/Hashimoto’s). Also, if this could be in moderately plain English, that would greatly be appreciated. How do we regulate, increase, and decrease SIRT1 as needed?

(sherry ) #2

Same here, but I just started keto.I have the same as you, except I had mine removed.How is keto working with this?

(Carl Keller) #3

I’m new to this topic and I found a really interesting but somewhat scholarly article about SIRT1. It said the easiest way to increase SIRT1 is to increase DHA and the way to increase DHA is to eat fish or take supplements:

Top Ways to increase SIRT1:

Lifestyle:

Diet:

  • Fish/DHA ®
  • Fructose – In liver, fructose increased SIRT1 production and activity (R)
  • Extra Virgin Olive Oil (R)

Supplements:

And here’s a really good article that talks about hypothyroidism and how it relates to keto:

https://drjockers.com/ketogenic-diet-hypothyroid/

(Kimberly) #4

So far, so good. I have much less inflammation (even though I supposed I didn’t realize I had so much before I started. Ha!), more energy, get up early in the mornings with no complaints from my over-tired body and have lost about 2.5 pounds per week. Honestly, I feel like I’m just biding my time until I’m fat adapted and really hope to settle into even more benefits of this way of eating.
I spoke with my endocrinologist about it last week. I figured I should since I’ve seen so many articles stating how terrible keto is for hypothyroid. Much to my surprise, he told me to keep at it and that it will be nothing but beneficial for dealing with this autoimmune disease. WAHOO!

(Kimberly) #5

Wow, what an informative article. Truly. Linking this back to the SIRT1 issue, from what I’ve read, it aids in insulin production and regulation, which according to this article, is vital in conversion of T4 to T3. This is exactly the issue for me in my AI journey. Very encouraging. Also, a ketogenic WOE is listed as one of the best ways to boost SIRT1 production (among many others including supplements).
I’m sorry if I’m just geeking out over here, but I’m intrigued by this entire concept. According to some reading, SIRT1 also enhances T3 effectiveness in your cells as well as stimulating T3 activity. For someone trying to muddle through solutions to help our own bodies deal with Hashimoto’s, this gives me some hope. I don’t want to be dependent upon medications to heal my body (don’t worry, I haven’t given them up), but want my BODY to heal itself and start regulating these hormones the way it was supposed to!
https://www.ncbi.nlm.nih.gov/pubmed/23922917

(Kimberly) #6

Also, I forgot to mention previously, I do still have my thyroid and am relying on levothyroxine (T4) and liothyronine (T3) to try to get it regulated.

(Carl Keller) #7

I’m really glad you liked the article Kimberly and I hope keto improves your quality of life. :slight_smile:

(Bunny) #8

How interesting?

Here is how to increase SIRT by supplementing with a little Brewers Yeast?

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells: Summary The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency. Murine SIRT1 attenuates telomere attrition in vivo and is recruited at telomeres in induced pluripotent stem cells (iPSCs). Because telomere elongation is an iPSC hallmark, we set out to study the role of SIRT1 in pluripotency in the setting of murine embryonic fibroblasts reprogramming into iPSCs. We find that SIRT1 is required for efficient postreprogramming telomere elongation, and that this effect is mediated by a c-MYC-dependent regulation of the mTert gene. We further demonstrate that SIRT1-deficient iPSCs accumulate chromosomal aberrations and show a derepression of telomeric heterochromatin. Finally, SIRT1-deficient iPSCs form larger teratomas that are poorly differentiated, highlighting a role for SIRT1 in exit from pluripotency. In summary, this work demonstrates a role for SIRT1 in the maintenance of pluripotency and modulation of differentiation.…More

Related:

[1] Shelterin (also called telosome): is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as regulate telomerase activity.