Here’s one:
This study was an RCT with 25 volunteers. They were split into three groups:
Intervention
After consuming a weight-stabilizing diet for 13 to 25 days, participants were randomized to diets containing 5% of energy from protein (low protein), 15% (normal protein), or 25% (high protein), which they were overfed during the last 8 weeks of their 10- to 12-week stay in the inpatient metabolic unit. Compared with energy intake during the weight stabilization period, the protein diets provided approximately 40% more energy intake, which corresponds to 954 kcal/d (95% CI, 884–1022 kcal/d).
These were non-exercisers, with BMIs between 19 and 30. While they all overate, the resting energy expenditure went UP ONLY for the higher protein groups, and was highest in the highest protein group. The lean body mass went DOWN for the lowest protein group, but went UP for both higher protein groups, and was highest for the highest protein group. By a lot: -0.70kg for low protein, +3.18kg (over 6 pounds!) for the highest protein group.
Also, note that they overate by 954 kcalories per day for 8 weeks (a theoretical gain of about 15 pounds or 7.x kg), but their actual weight gain was 3.16 to 6.51 kg, and the highest weight gain included more lean body mass and was for the highest protein intake.
Another one:
In this one, they used “resistance trained individuals”. They split them into two groups, high protein and control. High protein was really high, “4.4 grams of protein per kg body weight daily”. These were thin people. The high protein group ate over double the amount of protein and about 800 more calories as compared with the control. This was for 8 weeks. The result? Nothing. No differences in anything. So, the high protein people were able to eat way more calories (primarily of protein) and yet not gain any more weight. Again, so much for 3,500 calories = 1 pound of fat.
I have yet to find any RCT where higher protein was worse in some outcome than lower protein. I’ll keep looking, though.