Is cortisol one of the culprits?
This is what I’ve come to understand about the insulin hypothesis (which hardly is an hypothesis any longer, but oh well):
- Cells become insulin resistant
- Pancreas tries to compensate by producing more insulin to keep bloodsugar levels healthy
- High insulin levels means fat storing mode
- Low insulin levels allow fat burning mode
- High insulin levels causes overweight / obesity
- High insulin levels AND insulin resistance eventually lead to diabetes type two, because the insulin no longer can keep blood sugars low
In my head this means that you should somehow be able to gauge how insulin resistant people are simply by weight, but this isn’t the case, is it. Skinny people can be type two diabetic and fat people can be insulin sensitive (according to Ivor Cummings).
So I’m curious to know what other mechanisms drive obesity. Obviously there is high insulin and no access to fat stores - but why? If cells are insulin sensitive, blood sugars should be well managed and insulin low. What am I missing?
I’ll include the link to Ivor Cummings talk, it’s long, but very good - perhaps I missed some vital information in there
Edit: the slides I’m referring to appears around the 35 min mark