Misfolded form of pancreatic protein could induce type 2 diabetes symptoms


(Ross Daniel) #1

So if this is true, then a ketogenic diet must be able to counteract the misfolded proteins. I though this was interesting for sure.


(Crystal Michelle) #2

What does this mean…


(Bunny) #3

The short answer: toxicity to cells when pancreatic proteins are misfolded; are most likely too much pentose sugar (glucose) in the diet where the sugar is more abundant (i.e. misfolded proteins) than phosphorus to form proper nucleotides for DNA replication (retaining telomerase) or the homeostatic physiochemistry (fluids) surrounding the DNA, RNA and the way genes are expressed i.e. protein folding! (my guess)

On a deeper level it goes all the a way down to our DNA/RNA and the differences in the fat soluable, water soluable and insoluable physiochemical (fluids) environment around our DNA that we create through diet. e.g. when we are utilizing a ketogenic metabolism, fasting intermittently or extensively we are functioning (inter-intra-cellularlly) on a more microcosmic homeostatic scale, when we are a glucose burner (too much sugar) we are operating on a more macrocosmic scale and maybe a balance between the two is not what it should be?

Various Relationships:

  1. Role of gut microbiota-derived polyphenolic acid in attenuation of protein misfolding in neurodegeneration “…For example, gut bacteria metabolize soluble dietary fiber into biologically available short chain fatty acids (SCFAs) that may help modulate immune responses in the periphery and in the brain. Gut bacteria are also known for their role in converting dietary polyphenols into biologically available phenolic acids with anti-oxidant activities. However, there is little information on the potential role of SCFAs and phenolic acids in Alzheimer’s disease. The present study is designed to investigate effects of these SCFAs and phenolic acids in beta-amyloid (Aβ)-mediated pathologic processes that play key roles in AD pathogenesis. …”
  1. Spread of misfolded proteins could trigger type 2 diabetes
  1. Endoplasmic Reticulum (ER in bio-literature)
  1. Why is DNA shaped as a spiral? - A high school student from Australia May 3, 2005
  1. DNA helix has chiral water spine
  1. What Is the Advantage of Having the DNA Tightly Wrapped Into the Chromosomes? The DNA inside of a cell is organized so that it fits well within the small size of a cell. Its organization also facilitates the easy separation of the correct chromosomes during cell division. The degree to which the DNA is tightly wrapped can also affect which genes are turned on or off, by affecting the ability of certain proteins to bind to the DNA. The double helix of DNA is then wrapped around certain proteins known as histones. This allows the DNA to be more tightly wrapped and therefore take up less space within the cell. The DNA can condense even further by the histones coming into close proximity to each other. This even tighter winding of the DNA causes the formation of tightly wrapped, or condensed, chromosomes. “… Chromosome Condensation: Throughout most of the life of a cell, the DNA is only loosely wrapped around the histones and is not in the condensed chromosomal form. The tighter wrapping, or condensing, of the chromosomes occurs only during mitosis, the process of cell division. During mitosis, the chromosomes condense so that each chromosome is a distinct unit. Prior to mitosis, the cell copies its DNA so that it contains two copies of each chromosome. The chromosomes align in the middle of the cell during mitosis, with the pairs of chromosomes next to each other. When the cell divides, one copy goes to each of the resulting cells. If the chromosomes do not line up properly, severe genetic abnormalities can occur, which can lead to death of the cell or cancer. Condensing the DNA into tightly packed chromosomes makes the process of chromosome alignment and separation during mitosis more efficient. …” …More
  1. What is a Nucleotide?
  1. DNA Replication Mechanisms
  1. DNA Replication and Causes of Mutation
  1. Cells Can Replicate Their DNA Precisely How precisely?
  1. How to Personalize Your Nutrition Based On Genetics

(Ron) #4

Whewwwww Bunny…that one was so far beyond me, Pluto was in risk of disappearing. LOL :astonished::exploding_head:


(Crystal Michelle) #5

:joy: