The p value in this study is rather significant. This could be helpful information to those who have stubborn A1c and weight issues and not already taking Metformin.
Metformin and Knee Osteoarthritis
marklifestyle
(Mark Rhodes)
#3
I think it was the anti-inflammatory ability of metformin to modulate the cartilage degradation. Speculation is that it might alter pathways of cell survival and has some analgesic effect.
Recall that metformin activated AMPK and inhibits mitochondrial reducing ATP production. All of this means reduced gluconeogenesis which leads to greater insulin sensitivity. Synovial fluid does have epithelial like qualities and is activated by cytokines which create cartilage breakdown. Metformin DOES have an effect on intestinal endothelial cells so it stands to reason that it could have an affect on similarly structured cells.
lfod14
#4
I dunno, 2g of Metformin isn’t a little, and on a 0-100 pain scale, the difference at a full dose only causing a difference of 12.4 on a 0-100 over 6mo doesn’t seem too impressive.
Metformin’s great at doing it’s job, assuming people don’t have the teeth problem with it. Or in my case, horrible joint pain, conveniently my knees, if I use it daily.
marklifestyle
(Mark Rhodes)
#5
Pain scale is completely subjective even as measured by one person so there is that.