Ketones caught performing housekeeping

(Myth Buster ) #1
(Joey) #2

Fascinating. Thanks for the link.

Here’s the research paper itself…
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00459-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945624004598%3Fshowall%3Dtrue

(Bob M) #3

It is interesting. Makes me wonder if this is why MCT oils and/or exogenous ketones can work for people with dementia.

(Mark Rhodes) #4

I saw this early morning and posted in two FB groups I admin about brain Health and The Ketogenic Heart. Nick posted on this almost as fast as I did (almost) lol. https://www.instagram.com/reel/DDHjYDVuXOz/?utm_source=ig_web_copy_link

(Jane) #5

Exciting study for us!

However… since we always are suspect about studies funded by companies who would benefit from a specific outcome… This is from the study document (BHB Therapeutics make exogenic ketones).

Acknowledgments

This work was supported by NIH R01AG067333 (J.C.N.), a sponsored research agreement from BHB Therapeutics (J.C.N. and E.V.), Buck Institute institutional funding (J.C.N., E.V., B.J.S., B.S., and G.J.L.), University of Southern California (USC) Provost Fellowship Funding (S.S.M.), NIH training grants NIA T32AG052374 (S.S.M. and B.E.) and NIA T32 AG000266 (M.N.), Diversity Supplement NIH R01AG067333-02S1 (S.P.), the Larry L. Hillblom Foundation (G.J.L.), and biomaterials from the NIA Nonhuman Primate Tissue Bank. R-βHB-SNAC was received from Scott Ulrich at Ithaca College. All figure panels were created in BioRender.

Declaration of interests

J.C.N. and E.V. hold patents related to molecules described herein, licensed to BHB Therapeutics Ltd and Selah Therapeutics Ltd. J.C.N. and E.V. are co-founders with stock holdings, and BJS holds stock options, in BHB Therapeutics. J.C.N., E.V., and B.S. are co-founders with stock holdings in Selah Therapeutics.

(Jane) #6

Some more info on BHB Therapeutics and the Buck Institute.

https://www.pharmasalmanac.com/articles/bhb-therapeutics-launched-to-develop-medicines-to-prevent-age-related-diseases

Not disparaging the study… just adding additinal information on the basis and who is backing the study (i.e. who benefits).

(KM) #7

So frustrating, isn’t it? I’m tired of being part of a species that thinks money is the most important metric of all, power second, and truth (or consequences) running a poor third. It makes it a never ending slog through hell to get any empirical information any more.

(Jane) #8

I’m with you girlfriend.

I think the goal is to develop a drug for ketones they can patent and make billions off of.

sigh

I will keep making ketones naturally and hope to stave off the more serious brain issues as I get older.

Even if the studies are profit-driven, it is nice to see some confirmation that my fasting for autophagy might actually have positive benefits! And my keto diet can maintain the progress.