Glycine supplementation re: lastest podcast


#61

@richard Richard, have you had your torque test yet? If so, how did it go? (Fantastic, hopefully!)

Also, are you still taking the same amount of glycine every day, taking something else instead, or not taking anything now?

Thank you SO MUCH for lab-ratting this for us!


(Rob) #62

Just a point of order… you did reply to him but if you are the next reply in the list, it doesn’t say 1 reply or show the reply icon. It’s efficient and maybe more elegant but it is confusing. Discourse should fix that.


(Richard Morris) #63

Nope that is in a few weeks. Still taking a teaspoon every morning in my morning espresso.


#64

Just thought I’d post an update: Discontinued glycine supplementation and BG dipped back down into the 70s (was hovering in the 90s with the glycine supplementation). Don’t feel like the elevated glucose is worth the bump in ketones. Will be curious to see if anyone else experiences this phenomenon.


#65

Just curious, @Carikate, what time(s) were you taking the glycine, and what time(s) were you measuring BG?


#66

Thanks, Richard!


#67

I was taking the glycine at night before bed and measuring BG several times a day. It stayed elevated even in a fasted state (I do 16:8 IF six days per week). A week with no glycine and my BG dropped back down to the low 70s. Clearly not a scientific conclusion, but hated to add a new problem just for extra ketones :blush:.


#68

Thank you. I was just wondering.


(Carol O'Carroll) #69

Sorry if you’ve already answered this, but what is the difference between Creatine monohydrate and L Creatine if any please? My searches keep throwing up Carnitine? Thanks


(Richard Morris) #70

Sorry I mistyped. I can’t believe I typed that I meant to say carnitine.

Creatine is a cofactor for producing energy. I don’t supplement with creatine. Although potentially I could be short of creatine for the same reason I may be short of carnitine.

Carnitine is what I supplement. Specifically L-carnitine is the one that animals use (the other kind d-carnitine is toxic to us). It is used to shuttle long chained fatty acids into mitochondria to be burned.

We make Carnitine from amino acids (we also make creatine that way too) and one of the steps that we use (methylating the amino acid lysine) is one for which I may be genetically constrained by my methylation status (MTHFR mutation).

In theory for someone like me who methylates less efficiently carnitine could become a rate limit for how fast I can burn fat for energy. I have noticed less energy constraints when cycling so maybe Tommy Wood has a point. It’s not something that would build up if I get too much - I’d just be making expensive pee so I’m happy to supplement just in case.


(Cindy) #71

Glycine converts to gaba and opposes glutamine, which improves sleep. Insomnia is a severe problem for me, and glycine does help. Amino acids don’t help. So for anyone who need sleep help, glycine might be a good thing. But it’s concerning that it raises BG. I only take 1 g per night though - not the high doses you guys are talking about.


(Miss E) #72

Interesting that with some it’s wiring and others it’s assisting sleep.

I’ve just started taking ginger capsules to lower cortisol but I also have glycine (only tried both once so far). Wonder if that is over kill.


#73

That’s interesting considering the latest podcast about cancer. If Keto starves cancer of glucose and glycine can suppress glutamine, do we have a cancer treatment regimen here?


(Carol O'Carroll) #74

Has anyone had electrolyte problems, especially magnesium, doing this supplementation please?


(Diane) #75

I was supplementing with 100 mg of magnesium glycinate at bedtime long before I added in daily glycine. I haven’t personally noticed any symptoms that would indicate a need for more magnesium.

I just realized that I added in more pink Himalayan salt throughout the day at about the same time.


(Liz ) #76

I saw someone mention being kicked out of ketosis using glycine, wasn’t sure if that’s a thing for others? I don’t measure ketones but I did wonder if supplementing glycine would break my fast. Thoughts? Experiences?


#77

If by break fast you mean autophagy…I think 3 grams of the amino acid lysine stops that dead in its tracks. Not sure what glycine does…

Also, it might stop it dead but not for a long time since it’s only 3-5 grams


(Liz ) #78

Ok yeah, I was thinking autophagy, thank you


(Diane) #79

I do measure ketones and I haven’t had an issue being kicked out of ketosis (taking 3000 mg at bedtime, all the time, including fasts; only occasionally remembering to take 1000 mg with meals).

I don’t know about whether this breaks my fast (I’m fasting for autophagy). I always have had trouble sleeping and it’s worse with extended fasting. So, I take it because it really helps me fall asleep. I will say that it doesn’t seem to drive hunger for me: it doesn’t seem to make it harder to fast.


(Liz ) #80

Thanks for sharing your experience! I was using it in my tea during fasts & then I got nervous I was messing up my hard work so I stopped. But I sleep poorly fasted as well so I might add it back in at bedtime & see how I do.