Gary Taubes's argument that GLP-1 inhibitors work through fuel (re)partitioning

(Bob M) #1

In short, he thinks the GLP-1 inhibitors are allowing the body to access the calories stored in fat, and this is what causes people to (want to) eat less.

There’s an interesting mouse study of genetically altered mice (so called “transgenic” mice) where some took a drug and some did not, but they kept the calorie intake the same for both groups. Even though EATING THE SAME CALORIES, the mice taking the drug lost more weight. Why? Gary theorizes it’s because the drug provided access to the calories stored in fat, whereas the other mice could not access those calories.

As an aside, I think this is why some people can lose X pounds quickly (say X = 100 pounds), while it takes others a very long to never time to lose that weight. I think the latter have broken something that prevents the body from accessing the fat in the fat cells. I think hormones have a lot to do with this, including “insulin resistance” (by the hormone insulin), but this could vary a lot by person. For instance, menopausal women aren’t the same as men as far as hormones are concerned. I have no proof for this, other than it makes logical sense to me.

#2

I feel that’s just a rewording of what we already know of how GLP-1’s work. Once you’re on a GLP-1, you’re insulin sensitive, you’ll release more insulin when it’s needed because you’ll be receptive to that queue, because of that your blood sugar is only elevated long enough to do the job and not stay high longer than that, which means your blood sugar elevations (time wise) are minimal, and when that’s the case you can get a fat more often than when it’s chromincally elevated.

Me without Semaglutide will have an idle glucose level in the 105-115 range. I doin’t usually spike nuless I’ve been getting crappy sleep, which shows huge, A1C is usually low 5’s either way, but ith it, it’s usually in the high 80’s - low 90’s. With it I was able to get my BF% from the high 10’s to 9.2% at last check, eating in a surplus again now but going to try to hit the high 8’s next time. That definitely wouldn’t have happened without it.

Keep in mind that’s doing TKD/CKD!

I don’t pay retail gouge rate for it like most so long term isn’t an issue, but also have no intentions of it being a life thing either.

(Denise) #3

This topic interested me because since I had a hospital stay (pancreatitus never had before) of Tues-Saturday a couple weeks back, I have struggled to keep my BG down. I have a daily record, plus I know my numbers in hospital were high because they didn’t feed me my same keto diet, which I already knew that would happen.

I don’t have any problem with sticking to my Keto foods, (40% Protein, 50% Fat, 10% carbs or less)

I just read what Semaglutide is and even on my keto diet, my BG HbA1’c have still stayed in the 6.1 Pre-diabetes numbers. Can I ask why you do the Sema. injection? My BG’s are so crazy right now, it scares me. I keep thinking I’ll get back to more lower daily test-from-home, but they are still fluctuating after 2 weeks of being back on Keto :frowning:

I’m also rather disheartened because there is hardly any sort of studies (at least I can find) on Seniors like myself late 60’s to 70’s. I suspect there just aren’t many of us seeking better health :frowning: Like I think I have become invisible, heard that line in a movie/show.

(carl) #4

I was on Ozempic at low doses for a while, and got off of it because of what I was reading about it. Since then I have been using Allulose in my pre-meal and during-meal beverages, and I have noticed the same effects as when I was taking Ozempic. I am losing weight faster than before and am eating less. Then I hear about this study from 2018 https://pubmed.ncbi.nlm.nih.gov/29317623/ as summed up by this YouTube video https://www.youtube.com/watch?v=ZY2vU9I5uic. Good news for those who want the effects on the GLP-1 enablers at a much more affordable (and more delicious) price.