FOXO3 longevity - another victim of high sugar

(Karim Wassef) #1

We have investigated how lifespan is curtailed, rather than extended, by unhealthy nutrition in early adulthood. Similar to transient, lifespan-extending interventions, it is likely that the long-term, detrimental effects of diet-induced FOXO inhibition are also due to persistent epigenetic modifications. Indeed, DAF-16 engages the SWI/SNF chromatin-remodeling complex to increase worm lifespan (Riedel et al., 2013). Our gene expression data show that, in Drosophila , a sugar-rich diet represses dFOXO to drive changes in expression of a number of epigenetic modifiers, which is likely to have substantial consequences for the epigenome. Elucidating these dfoxo -dependent epigenetic changes and how they could be reversed may form the basis of future treatments to remedy the cost of past diets.

Basically, high sugar inhibits FOXO and reduces longevity by reducing the body’s adaptability.

#2
(Karim Wassef) #3

different kind of sugar… but nice…

(Bunny) #4

Wow hope this isn’t true with humans?

Fruit flies are meant to eat sugar?

“…Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian physiology to cause long-term, detrimental effects. Here, we show that, in Drosophila melanogaster, an unhealthy, high-sugar diet in early adulthood programs lifespan to curtail later-life survival despite subsequent dietary improvement. Excess dietary sugar promotes insulin-like signaling, inhibits dFOXO—the Drosophila homolog of forkhead box O (FOXO) transcription factors—and represses expression of dFOXO target genes encoding epigenetic regulators. Crucially, dfoxo is required both for transcriptional changes that mark the fly’s dietary history and for nutritional programming of lifespan by excess dietary sugar, and this mechanism is conserved in Caenorhabditis elegans . Our study implicates FOXO factors, the evolutionarily conserved determinants of animal longevity, in the mechanisms of nutritional programming of animal lifespan. …” …More

(Bunny) #5

One other thing how are you going to improve the diet of a fruit fly who is starving to death from lack of sugar? …lol

When anything that isn’t human is malnutritioned from its native dietary intake and starving to death it is hard (almost impossible) to reverse it no matter how much food you feed them to try to keep them alive?

(Karim Wassef) #6

maybe it’s a glucose vs fructose diet?

or maybe it’s that their dependence on sugar naturally forces them into shorter lives

(Bunny) #7

Hummingbirds are a brilliant example and the only creature on earth that can burn glucose and fructose equally[2]?

The most awesome metabolism on planet earth!

Taking a bath…lol

image
88D6D92C-5204-4D04-A1B3-5846FA258880.jpeg900Ă—720 81.8 KB

[1] “…A hummingbird’s heart beats from 225 times per minute when it’s at rest and more than 1,200 times per minute when it is flying. Its wings beat about 70 times per second in regular flight and more than 200 times per second while diving…” …More

[2] The exception to the rule: Hummingbird metabolism unique in burning glucose, fructose equally: Now new research from the University of Toronto Scarborough shows they are equally adept at burning both glucose and fructose, which are the individual components of sugar; a unique trait other vertebrates cannot achieve. “Hummingbirds have an optimal fuel-use strategy that powers their high-energy lifestyle, maximizes fat storage, and minimizes unnecessary weight gain all at the same time,” “If we can gain insights on how hummingbirds cope with an extreme diet then maybe it can shed some light on what goes wrong in us when we have too much fructose in our diet,” says Kenneth Welch, assistant professor of biological sciences at UTSC and an expert on hummingbirds. …” …More

(Bunny) #8

Speaking of which, I was sitting outside yesterday and a hummingbird was trying to poke its beak into my ponytails balls on my head (they are letting know they are hungry) so I just went to Lowe’s a little bit ago and bought two humming bird feeders because I have several bags of powdered hummingbird sugar sitting in the cabinet for them to eat, my last hummingbird feeder broke and I never bothered to replace it…lol