Making this into it’s own topic.
A review of a recent study in mice. Typically mouse studies that are called “high fat” are also high in carbs. This one tested the difference between HCHF and LCHF and found huge differences in trial outcomes. Many people do not include the effects on the brain and its complex regulatory role in energy balance when talking about diet composition.
http://breaknutrition.com/study-review-dietary-sugars-not-lipids-drive-hypothalamic-inflammation/
Link to full study:
Wow, Carol, that is a serious read. 
I had never heard of “hypothalamic inflammation” before, but in reading about the hypothalamus, I see it described as the area of the brain “that exerts central control over peripheral glucose, fat, and energy metabolism.” Sure sounds like we want our hypothalami to be happy, keep cool, etc. - at the least we want our autonomic regulation to be unhampered.
There are some significant statements at the bottom of that webpage, in parts 4 and 5, “Discussion” and “Conclusions.”
Also, yet again - the situation where “high fat” gets the blame for what is due all or in part to carbohydrates rears its head. Such a pervasive thing, it seems. Ugh.
Yes. I find it interesting that so little of the debate about the insulin hypothesis treats the brain as an innocent bystander, while the liver and pancreas are discussed endlessly. Also, the adipose tissue, gut incretins and microbiome are usually not incorporated as part of the feedback loop.