Interesting article with good references… also worth reading the comments, there is lots of resistance from the usual sources. I don’t know if you need a substack membership… hope not.
Carnivore article worth reading…
I like that.
This is both true and not true:
Hyper palatable foods high in refined carbohydrates, sugars, and artificial additives - hallmarks of a typical modern diet - interfere with these hormonal signals. For example, high-sugar foods cause rapid spikes in insulin levels, leading to insulin resistance over time and impairing leptin signalling.
Protein also causes rapid spikes in insulin.
I think the difference is that you’re not spiking insulin nearly as much on a carnivore/keto diet as you would be on a high carb diet. For high carb, it’s easy to eat 3, 4, 5+ meals/snacks a day. But it’s much harder to do that with eating carnivore/keto, where most people eat 2 or maybe 3 meals a day.
Also, if you’re eating 70%+ fat, you’re probably not spiking insulin as high as you would with some carbs.
As far as leptin signaling, I don’t know what to say there. I don’t know enough about it.
I didn’t read the article… yet but I thought the issue of protein causing a rapid insulin response was debunked… for sure I haven’t been keeping up with the science so maybe there is new evidence of this?
It was the opposite for me but of course some people are outliers But it’s logical to me that as high-carb wasn’t so satiating for me, I ate bigger, fewer meals. Apart from some compulsive eating or something, I never had more than 2 bigger and one tiny meal on high-carb, it couldn’t fit, I almost never went over 4000 kcal and that’s 2 bigger, borderline big meals in my world. 5 meals a day was a stranger to me until carnivore but I managed to get rid of those annoying days (5 tiny meals… horrible). Even OMAD and EF was way easier with carbs due to the bigger meals.
I can’t eat intuitively (whatever it means) and expect good results but indeed, choosing the right diet is very important, it may help in ways we wouldn’t think it’s possible. My fav is when I manage to eat a satiating and lean enough way (not that easy for me but there are items for that I actually like) - and it doesn’t matter what my appetite does and how one little part of me wants to self-sabotage me, it just can’t happen as I am just so satiated (not really the extent, the type of satiation if it makes sense. it does to me) that eating isn’t an option. Mere satiation never was enough in my case but when I thought oh, my habits and behaviour just doom me, it turned out the right diet solves even these problems. Not like I have any results this far but I see it will work if I keep trying to focus and choose my food well.
And of course, some people is way better on a carbier diet, be it fat-loss or just living (and calorie counting may not be needed at all for a successful, carby fat-loss) but I understand why avoiding most carbs is useful for many people, possibly for most, who knows? But even on keto and even on carnivore, there are often problematic items so additional rules, changes may be needed to get success.
Is that what your testing shows? Bikman says his data show that any insulin increase from protein consumed in the absence of carbohydrate is matched by an increase in glucagon, leaving the insulin/glucagon ratio unchanged. This keeps the metabolic milieu of the body unchanged.
On the other hand, when carbohydrate is consumed along with the protein, it inhibits the secretion of glucagon, and the resulting insulin rise is larger, there is nothing to counteract its effect, and therefore the metabolic milieu is shifted from metabolising fatty acids to storing them.
Thank you Paul for that explanation. My understanding was far simpler but the gist was that protein doesn’t really insulin. Now I have a clearer picture.
I thought that the better way to look at the picture wasn’t to emphasize that “Protein also causes rapid spikes in insulin” but that protein causes a smaller spike in insulin. I don’t think the speed is as important as the size of the spike.
The size of the spike is strongly influenced by the insulin/glucagon ratio, so that’s why protein is the much better choice than carbs.