They are probably talking about things like mowing your yard, walking your dog, hyperbaric welding, those sorts of things.
Bob Harper host of Biggest Loser had a heart attack
ketoerika
#139
to follow up on this. It looks like Bob had high levels of Lp(a) http://people.com/bodies/bob-harper-heart-condition-i-dropped-dead/
Bahrutile
(Dustin Cade)
#140
I’ve heard about these proteins, though is an elevated level really cause for alarm?
perhaps @richard could shed some light on this…
richard
(Richard Morris)
#141
A lot of things about Lp(a) are still hypotheses
Lp(a) appears to be an anomaly in the structure of a protein on the surface of lipoproteins you make that causes them to be difficult to clean up when their job is done. It’s an inherited trait that causes you to make more anomalous than normal ones. It’s essentially an LDL with an Apoplioprotein A on it’s surface that shouldn’t be there, and it has a long tail that your cells can apparently be mistaken for an inflammation repair material called fibrinogen.
Normally after a certain time in circulation delivering lipids, our lipoprotein particles acquire a protein (Apolipoprotein E) on their surface that allows them to be taken out of circulation (70% by the liver 30% by other cells). The longer they are in circulation the weirder they get - oxidized, or glycated - the blood they travel in is a very reactive environment full of dangers for lipoproteins.
So anything that causes LDL to stay in circulation longer is bad. Lp(a) makes it more difficult to pull out of circulation. So your lipoproteins hang about longer and tend to be weirder than most.
That “clear me” protein comes from your energy carrying particles (Chylomicrons and LDL) bumping into HDL particles, which may be why the more HDL you have the better your health. Even if you make a lot of Lp(a), the more HDL you have the more chances it’ll get taken out of circulation in a timely fashion. So maybe a diet that promotes HDL is good for people who make Lp(a).
When you have inflamed blood vessel walls, your body will recruit resources to fix that from circulating LDL and if your LDL is weird … you’ll apparently get unstable repair jobs in the wall of your arteries. And that is likely one of the causes of atherosclerosis, which causes thrombosis and occlusion around the vessels feeding the heart, or brain and … well that’s bad news. The fact that these specific LP(a) particles are also mistaken for fibrinogen means they are more likely to be found around blood vessel repairs.
The fact that cell wall inflammation can be caused by high levels of insulin also means a diet that causes you to make less is going to be better for people who make Lp(a).
Lipoprotein (a) increases in a low Vitamin C diet?
richard
(Richard Morris)
#143
Almost everything I know about lipoproteins I learned from Ken Sikaris and @DaveKeto
Dave65
#145
Video reviews the data obtained from studying mice model where the mice can’t make vitamin C and make LP(a).
A normal mouse makes vitamin C and doesn’t make LP(a).
Other than humans; guinea pigs, bats and dry-nosed primates have lost their ability to produce vitamin C.
They report that vit. C deficiant mice have severely damaged arterial structure compared to mice that are fully supplemented with C. The only difference between the control and experimental group was the amount of vitamin C given. Artery wall thickens where LP(a) is deposited providing structural reinforcement against hemorrhage.
In the lack of sufficient vitamin C the LP(a) acts like a patch to repair damaged artery.
richard
(Richard Morris)
#146
Awesome video. Thanks for that.
I knew that VitC is necessary for building collagen structures, but the relationship to Lp(a) is fascinating.
BTW If Bob Harper was Vitamin C deficient on his pre-heart attack “healthy” diet then he needs his ass kicked.
KetoLikeaLady
(What The Fast?!)
#147
Right?? I always feel like I need a “TL;DR” when he whips out all the facts. Can someone write a “Keto Research Stuff for Dummies” book?
Mike_W_Ellwood
(Michael Wallace Ellwood)
#148
Right. No one actually needs a CAC score, or a DXA scan or whatever, to do keto. One can use scales, a tape measure, relatively cheap glucose and ketone monitors & a relatively cheap BP monitor to get some indication that things are going the right way, as well as response to exercise and how one feels.
Mike_W_Ellwood
(Michael Wallace Ellwood)
#149
Owen Fonorow of the Vitamin C foundation is a strong promoter of the Pauling / Rath protocol for heart disease:
http://practicingmedicinewithoutalicense.com/
He’s also quite keen on vitamin K2 for de-calcifying the arteries. I think we now know a lot more about vitamin K2 than was known when Linus Pauling was still alive.
Aqua_chonk
(Stickin' with mammoth)
#151
(sigh) Unfortunately, it seems Bob has learned little from his experiences.
stacy
(Keto in Katy)
#152
When I hear someone attribute health issues to “genetics” I think it usually means “I don’t know WTF is happening here so it must be genetic.”
Bellyman
(Brian)
#153
While I still have respect for those who want to eat a plant based diet, I also know a LOT of vegans and vegetarians personally. Unfortunately, there are way more of them than I think they’d like to admit that have heart (and other health) issues.
I am close to quite a few of these people, some are like family… a few are family…, and I love them dearly. But they’ve been indoctrinated to believe that animal products and fats are evil, carbs are good, and sugar is ok (as is evidenced by the weekly potluck), so much so that they are often more content getting drugs from their doctors than working towards figuring out what the real problems are. For some, trying to convince them that not all carbs are equal is monumental, let alone the idea that it’s best to just leave the sugar behind completely. For many, they can’t seem to wait to try out the latest chemical concoction that tastes like and has the texture of meat. UUGGHHH!!! …(and then call it “health food”.)
Not all, I’ve known some very healthy vegetarian types. They tend to be very proactive in getting their nutrients. Unfortunately, that’s a small minority in the circles I travel. I suspect if you’re reading this, you probably are in the minority that are thinking about how you’re getting your nutrient needs met, and that’s good, not just about whether what you’re about to eat had a mother.
Cilantromee
#154
I saw Bob Harper on the Dr. Oz show yesterday.
Surprise! Surprise! Bob Harper claims that he was on a paleo diet prior to the heart attack - a typical spread of the paleo diet is included in the shot: “lean” meats, green leafy vegetables, nuts and healthy oils. Dr. Oz chimes in to say that it is a healthy diet except if you have a genetic condition like Bob.
Then Bob proceeds to show us his current diet: eggs whites (eww), greek yoghurt with cereal (!!!), tofu and veggies, quinoa, quinoa, quinoa and fish. Dr. Oz says how it’s essential to include some healthy grains and cereal in a good diet.
Bob also mentioned a doctor that is helping him with his new diet, a referral from Dr. Oz apparently. I didn’t catch his name. This doctor wanted Bob to go vegan but Bob couldn’t give up the fish. 
In retrospect the food display segment of the show seemed awkward. And all I seemed to hear was “eat carbs” and “go vegan”. 
LeeAnnJ
(Lee Ann)
#155
Does anyone know of any human studies on fasting and Lp(a)?
I found this article on Cynomolgus Monkeys that they think may me a good model for studying Lp(a), but didn’t find any human studies.
Excerpts:
The present study showed that the plasma Lp(a) levels in cynomolgus monkeys show large individual difference similar to humans. Complete fasting for 4 days decreased the plasma Lp(a) level in a monkey with a high level of Lp(a), and this decrease continued after banana feeding. The Lp(a) level returned to the original level by feeding normal monkey chow to the monkey. On the other hand, a monkey with a low level of Lp(a) and a monkey being fed half the amount of monkey chow as the other two monkeys showed no effect on Lp(a) levels.
These results show that high levels of plasma Lp(a) may be decreased by fasting or feeding of certain foods. Therefore, diet may be used as a method of preventing and/or treating high Lp(a) levels. This study indicates that the cynomolgus monkey can be used as an animal model in place of humans for research of plasma Lp(a) metabolism. However, since we used only 3 monkeys, further studies need to be performed to clarify this.