Biohacker: Bryan Johnson:

(Luke) #11

Hi. I started watching a documentary about him on Netflix , it’s pretty out there. The amount of supplements he takes is astonishing , it’s literally hundreds , I stopped watching it , but pretty sure he is not keto.

(Bob M) #12

Nick Norwitz discussed Bryan Johnson here:

Apparently, we should be taking omega 3 pills.

(Ohio ) #13

Comparing him to Tom Brady is a low blow. Lets have some dignity here.

#14

Who is the lady who spends $2000 a year? Would love to try that

#15

Julie Gibson Clark. I was wrong about the amount, more like $1300/yr

https://www.nad.com/news/gender-dynamics-in-the-longevity-market-one-woman-triumphing-over-men-with-budget-friendly-anti-aging-solutions

#16

Interesting, I had no idea there was a competition.

Do you think people’s genes play a role? Obviously they do but I mean in terms of this competition, do people whose parents are centenarians have an advantage in this game?

I am familiar with methyl groups and their epigenetic influence on DNA. Without having done any research!!, I would think the answer should be yes, otherwise methyl groups are a nice red herring but not the true indicator. Wondering if any research has been done on comparing the methyl group aging of centenarians (or their children if both parents) with people who seem to be aging rapidly. For example, I know people in their mid 80s who walk miles, bike and play tennis three times a week at a competitive club level and are planning a bike tour of the Poconos. Then I know people in their early 80s who have trouble going to the grocery store

(Ohio ) #17

It appears my hero’s vegan diet has caught up to him. Autoimmune issues, he’s recently gotten into a smorgasbord of pharmaceuticals as well. I don’t agree w/ a lot of what he does, but it’s unfortunate as I totally agree with his logic that civaliation doesn’t have a good handle on human longevity. Give AIP a chance ppl !

(Edith) #18

I’m starting to believe anything done to the human body to the extreme is not healthy. Even being a professional athlete and in extremely good physical condition comes at a price. Unless one has nutrient deficiencies, popping megadoses of vitamins, minerals, and other supplements in quantities way outside of what nature provides while helpful in the short term for one reason or another is probably not healthy for the long term.

I just have one anecdotal story involving me and my family. I won’t go into how I figured it out, but I realized that taking B-vitamins was making me edgy and mean. I mentioned it to my daughter and her boyfriend because they liked drinking energy drinks. My daughter said when they stopped drinking drinks with added B-vitamins, they stopped bickering nearly as much. B-vitamins are touted as the wonder vitamins and are added to a variety of drinks. Supposedly, one pees out the excess as they are not fat soluble. Well, in my family, we discovered we can still overdose on them.

There’s evidence now that leaky gut contributes to autoimmune issues. I wonder if all those supplements (and the vegan diet) damaged his intestinal lining?

(Ohio ) #19

IMO the plants fight back. 90% of plants are toxic. Something’s gonna happen. I still do keto vegan; in June specifically when all the plants here are fruiting and everything is free.

I feel like weightlifters, younger than me, are dropping like flies. I’ve considered starting a seperate thread just for that phenomenon constantly showing up in the news. Especially fitness influencers.

(Bob M) #20

@VirginiaEdie There is something bad about too much exercise. It’s easy to find studies where they look at the hearts of high-output exercisers, and many of them are very atherosclerotic. The theory I think makes the most sense is that there’s constant damage to your arteries, and if the repair >= damage, you’re good. If you’re exercising a ton and don’t recover enough, then damage > repair -> atherosclerosis. I think the same applies for smoke, smoking, viruses, stress, etc., where too much means damage > repair -> atherosclerosis.

I take B vitamins because I’m part MTHFR, meaning that my homocysteine is relatively high. I take methylated B vitamins (a problem for MTHFR is methylization) to attempt to lower homocysteine. But I can tell if I take too many - I don’t feel great. I haven’t found the perfect amount to take yet.

I think @Hippie might have the correct assumption – plants aren’t good for everyone, especially in high doses. And while I believe the biome does something, it’s hard to know what the effects are. Some can be healthy eating fiber and (some) plants, and some can be healthy eating zero fiber and no plants.

And I think people are different. I tend to do well with lower amounts of plants and – particularly – fiber. But others seem to be able to eat more plants and fiber. And I only found out about plants and fiber by eating a lot less and then realizing when I ate more what happened to me.

I was a pseudo-body builder when I was younger. Never took drugs. Got bigger, stronger, but nowhere near what people think of as a “body builder”. But it’s amazing how many of them died younger. Due to the drugs? Or something else?

#21

Indeed. But on YT, I always see people (commenters and influencers alike) telling everyone fiber is the key for fat-loss and it’s so vital… It’s obviously not, why don’t people know that? My body was happiest on carnivore (I just want my little plant matter too in the long run… and I can’t avoid fruits at all. and I can handle a plantier, carbier diet pretty well as long as I don’t go too far too often) and fiber has the same zero effect on my satiation as volume. Oh yeah volume eating is a big thing too. And I understand it’s great for someone but they act like it would be something common for all humans…
It’s amazing how off people can be when it’s about nutrition. One would think we have so much information now that at least experts know things are individual and fiber isn’t essential… Just some people need it, like carbs. But nope. It’s virtually always volume and fiber and vegs and fruits (maybe I don’t get the right channels? but I do think this are quite common). Some influencers even think a diet without avocado and berries is a wrong diet… Wow. (I am pretty sure most humans didn’t even see an avocado before. Or not often. I definitely saw no one in my first decades…)

(Edith) #22

If you are eating a lot of meat, you might not even need to take B-vitamins. The B-vitamins found in whole foods are naturally methylated. It is the supplements that you have to worry about. I believe since I eat fairly close to carnivore, my B-vitamin levels are optimal which is why I can’t take them as supplements.

(Ohio ) #23

Another update: He’s eating meat now. He’s reading our posts.

(Bob M) #24

I don’t really know. That’s the problem with all of this. For instance, depending on the day I get tested and by whichever person you read, my homocysteine is high or near high, and this is supposedly due to a lack of B vitamins. The last one I got was 12.8 umol/L I’ve gotten anywhere between 10.2 to 17.9 over the last 10 years. The “official” high on this last test was 15.2, but others say it should be under 10.

To get this lower as a part MTHFR, I’m supposed to take methylated B vitamins. I think I got a lower value this time due to the methylated B vitamins I’ve been taking, but it’s hard to know since I only get tested yearly.

For my last test, my ferritin was low at 27 ng/mL. On the test, the “low” was 24. I’m concerned about that. But apparently I needed to get a “saturation percent” done for iron, which I did not get done. The last time I got this done, I got a 20 percent, which is the lowest of the low end.

Even though I’m eating a lot of beef, I’ve started taking iron supplements, and I’ll likely keep taking some B vitamins supplements. The issue is always how much to take, and I don’t have a good way to determine that.

Some of the ferritin issue is probably caused by my giving blood, but I got this test done about a month after giving blood. I think my ferritin should have recovered, but I’ve never tested it before giving blood then after. I don’t know what happens.

Anyway, as always, it’s complex. And I don’t have any good answers.

(Edith) #25

Well, that’s interesting!!!

I know nothing about this except out of curiosity, I just did a little info search on the web. When I looked up causes for high homocysteine, besides deficiencies in B-vitamins, it also mentioned that certain medications can cause high homocysteine and it specifically mentioned Metformin. (This was the AI Overview, so take it for what you will.) You mentioned a while back that you take Jardiance which is also used to treat type 2 diabetes and you’ve been suspicious of it causing your blood sugar spikes at night. If it’s mechanism is similar to Metformin, could that be possibly contributing to your higher homocysteine levels?

(Bob M) #26

That’s possible, but I think they operate differently. And I’ve had “high” homocysteine for well over a decade, but have only been on Jardiance for about 1.5 years.

What I think Jardiance is causing (in addition to the bizarre night fluctuations in blood sugar) is higher triglycerides. Mine used to be close to my HDL (near mid-50), but now are >100, 135 just a few weeks ago.

(Edith) #27

I found Bryan Johnson’s post about eating meat. I don’t think he did it because he is suddenly becoming a meat eater.

"I went off protocol and ate meat.

While traveling in Australia, I tried to fit in with social norms and ate animal protein for the first time in six years.

Here’s what happened…

It changed my gut microbiome:

+ good bacteria dropped 61% (the fiber-eating kind… Roseburia and Agathobacter)

+ fat handling, bile tolerant bacteria jumped 2.5x (+154%)

It made for a good experiment.

To be clear, I am not against meat. Plenty of omnivores have perfectly healthy microbiomes too.

This only shows that in me, after six years of legumes, pea protein, hemp protein, vegetables, extra virgin olive oil, berries, nuts, seeds and collagen peptides, one week of animal food left this unfavorable signature.

*The scientific details of what we learned: *

*1) Gut bacteria digest fiber to make butyrate and SCFAs, which repair your gut lining and turn down inflammation. I had 61% less which means my gut wall was possibly more vulnerable and I had less protection against inflammation. *

2) The animal food sources had my body generate more bile which acts a bit like a detergent, killing off sensitive good bacteria and enabling tougher, tolerant ones to take over. There’s some early evidence these shifts can happen within a day of eating animal food.

TO BE CLEAR: you eat what you want. I support you. I am not trying to get you to eat what I eat. I’m sharing experiment results from measuring my body."

(Niko Neko) #28

Bryan Johnson is fascinating because he’s almost translucent like a china cup. :thinking:

I feel really bad for him, he seems so alone.

(Ohio ) #29

Right. He’s got autoimmune stuff going on. Those ppl gravitate towards keto.

Hard to feel bad for a multi-millionaire, but yes he does seem alone. Even w/ a brand new g/f. I still think he’s making a valid point about human longevity.

(Niko Neko) #30

I grew up around ranchers and Native Americans, and I keep thinking that the square hearty meals, long days in the sun and brotherhood of horsing around with the other guys with the addition of endless physical labor would fixed the translucent man right up and give him a sense of meaning and purpose. Maybe that’s a sort of funny way to think of things though :stuck_out_tongue_winking_eye: