I’m never a big fan of euphemisms. They tend to wear out every so often, and then we have to find replacements. I’d prefer to be frank, if it’s possible to do so without being brutal.
“Obese” as an insult is a new one on me, however; it is the medical term for “fat,” and should be immune from provoking insult. You might just as well take offense at “diabetic” or “heart patient.” Frankly, I’d expect objections to “fat” as being the insult, not “obese.” Oh well.
The words I really object to are “pee” and “poo.” It always sounds hilarious when an adult uses them to anyone but a child. If you can’t stand the tedium of blurring out “piss” and “shit” every time they come up in conversation, why not use the medical terms, “urine” and “faeces/feces”?