AS alters the gut's response to glucose article

(KCKO, KCFO 🥥) #1

Habitual consumption of artificial sweeteners commonly found in diet drinks alters the gut’s response to glucose — affecting absorption, glycemic response, and response of gut glucagonlike peptide 1 (GLP-1) — results of a small, first-in-human study in healthy volunteers indicate.

medscape.com/viewarticle/885945

(Rachel) #2

What does this mean if you have been a diet coke consumer since you were 10.

(Cathy) #3

I can’t access the article as I don’t have an account. I wonder if you could elaborate what was being reported? Thanks in advance.

(KCKO, KCFO 🥥) #4

Here you go, site is a free one, not sure why you couldn’t access it.

Findings Provide Impetus for Larger Studies in This Area

The findings highlight “the potential for these responses in habitual consumers of artificial sweeteners and support the concept that artificial sweeteners could reduce the body’s control of blood sugar levels, exaggerating postmeal glucose levels, which could predispose them to developing type 2 diabetes,” Dr Young remarked.
He also noted that the results provided an impetus to perform larger studies and look at the mechanisms responsible. “We are doing this by looking at cells collected in this study as well as looking at the microbiome,” he said, with a view to the next steps in his work.
Commenting on the results, session attendee Viktor Jörgens, MD, former executive director of EASD, from Dusseldorf, Germany, said it was a “brilliant study.”
He remarked, “Because less glucose goes to the L cells, these cells make less GLP-1, and this is the reason these individuals have less insulin and higher glucose. I believe this study has enough power to say that this is indeed the mechanism, and it works this way.”
Dr Young has declared no relevant financial relationships.
European Association for the Study of Diabetes (EASD) 2016 Annual Meeting. September 14, 2017, Lisbon, Portugal. Abstract 193

(Cathy) #5

Thank you very much for providing the quote. The site asks for a sign up and I resist that.

“Because less glucose goes to the L cells, these cells make less GLP-1, and this is the reason these individuals have less insulin and higher glucose.”

I thought this statement was interesting because most people here are insulin resistant and therefore have a higher fasting insulin and presumably non fasting. It would be great to see the study and understand what and how they are talking about.