Article about GLP-1 and enteroendocrine L cells (insulin resistant folks produce less hormone)

(Bob M) #1

This is based on a Ben Bikman Instagram post. He was talking GLP-1 and wondering why some people don’t have a good GLP-1 response (GLP-1 is a hormone released after/during eating that makes you full or at least less hungry).

There are cells in the intestine that produce GLP-1: enteroendocrine L cells. He said that some people’s L cells produce a lot of GLP-1, while other people’s L cells don’t. He believes the L cells can become insulin -resistant and stop producing GLP-1.

This is a study he referenced:

In short, they use a variety of techniques to show that insulin resistant L cells produce less GLP-1, meaning there’s less turning off hunger for insulin resistant people.

I think that’s a problem I still have, since eating makes me hungry and it takes a while to back off that hunger.

#2

A very interesting episode of the Low Carb MD podcast where they talk about using terzepitide (GLP-1 + GIP) on fat adapted people in nutritional ketosis who are unhealthy, and doing low carb keto WoE to regain health.

A key point in the discussion is the testing of a 0.6mg once weekly dose of terzepitide. The reason for that dose is that it is the smallest droplet volume dose possible of the standard formulation. The aim of the therapeutic plan is to attain goal weight and consolidate healthier food relationships.

The mainstream starting dose is 2.5mg once weekly and comes with real side effects risks. Some people stay on it at ever increasing doses. In the anecdotal observations are case examples of almost life-long insulin resistance and metabolic dysfunction patients that do not respond well (ketone production and/or body fat loss).

Dr. Ben Bikman is an advisor on the clinical trial.

(Jane) #3

There is so much we don’t know about “metabolic health”.

I could eat anything I wanted until I birthed my first son at age 25. WHAM! Metabolism shifted and I couldn’t figure out why I couldn’t lose weight eating what I ate before my pregnancy.

I have known rail-thin people who ate like field-hands their whole lives and never gained an ounce. I had a roommate in college who ate twice what I ate and she was looking for dessert after dinner, which I never had and never gained an ounce. We both got about the same amount of exercise, so neither of us were sedentary and I was in my late teens/early 20’s.

My metabolism never recovered from having babies, but I wouldn’t trade a thin body for my boys!!! I still eat half what my husband eats, way more strict keto than him and weight about 10 lbs less and a few inches shorter than him.

If they ever figure out how to fix a slow metabolism (keto didn’t but at least I am not fat now), it would be a game-changer.

(Jane) #4

And according to my HOMA-IR score of fasting insulin and glucose I am not insulin-resistant anymore. Thankfully on keto I can eat smaller portions and not be hungry. But still puzzling to me…