Anyone worried about high LDL should watch this…
Interesting. But when the risk of a “cardiovascular event” is around 3%, how many events are prevented by a 12% reduction? In other words, what is the number needed to treat? I somehow missed the absolute numbers, if they were there. They also failed to look at the effect of lowering cholesterol on all-cause mortality which, we know from epidemiological data, can be significant. (Certainly more clinically significant than the effect sizes mentioned here.)
At any rate, as Austin Bradford-Hill is supposed to have remarked, unless the effect size is greater than 2.0, the study is not worth getting out of bed for.
You mean like this one? https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4045947 or maybe this one? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464539/ How about this one?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757859/ One more for fun? https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1251873/full