I always felt there was something a bit off about Prof Longo… seems my instincts were correct
“Fasting” candy bar… and Dr Khan hmmmm maybe not…
Valter Longo shows his true colours?
MarkGossage
(bulkbiker)
#1
Can we please stop repeating the “You have to eat at a deficit to lose weight on KETO” lie?
EZB
(Ethan)
#2
Yeah… they often cite fasting mimicking and claim it’s the same as fasting. It only mimics part of fasting—and it’s a trademark when used as they do. They are selling a product—a candy bar. It has 8g of sugar. It’s not fasting. It’s not even keto friendly for many due to the high carbs per calories. Sell outs.
daddyoh
(Eric - The patient needs to be patient!)
#3
This is so sad. This is what got us into trouble in the first place. Just say no to processed food.
anon54735292
#4
Don Layman tore one of Longo’s papers apart on Human Performance Outliers - it was gold 
MarkGossage
(bulkbiker)
#7
Did you see the twittersphere has renamed it the “fasting gimmicking” diet…
EZB
(Ethan)
#8
No, I hadn’t seen it, but it is fitting! The whole diet, at best, only mimics fasting by a couple measures—insulin and glucose. Even there. Some of the sweeteners and sugars will affect many people to no longer even mimic a fast on those measures. It’s marketing, and it confuses people about what fasting and keto really are. Products can be constructive when honest. That is, the same bar without the claims about “fasting mimicking” could be constructive with the understanding that whole, real foods, while ideal, are not always feasible or easy to obtain. Outlandish claims are clearly dismissible and reduce the perception of credibility of the movement associated with keto.
Alecmcq
(Alec)
#9
Wow, that is some guest list. I was not aware of this podcast, it is now on my must listen list. Thank you!!
MarkGossage
(bulkbiker)
#10
The couple I have caught up with have been great… the Don Layman one especially… he pulls Longo apart quite nicely…
atomicspacebunny
(Bunny)
#12
There maybe something to this if your a “yeast?” …lol
I wonder what it really means for humans?
Study was done on yeast, rodents and 71 humans, so maybe it might work? (all bases covered?)
Wonder what the proprietary ingredients are? (yeast?)…lol
I think the difference is the timing (IGF-1), protein (et al. fat & carbohydrates) intake vs. fasting?
image link
image link
Fasting diet reduces biomarkers for aging and disease
The yeast test was the closest to actual fasting. Researchers moved yeast between a nutrient fluid diet to water every two days. The results showed that prolonged fasting in yeast resulted in a longer lifespan.
The research institute also put rodents on a fast-mimicking diet twice a month for four days. At the end of each FMD period, blood glucose levels were 40 percent lower, a finding the study’s authors suggest may show that fasting can help with diabetes and other degenerative diseases. The results, published in Cell, noted that the mice, even after returned to a regular diet and biological readings, still had less tumors, inflammation and other health issues associated with age.
In a small study of 71 people, the FMD diet didn’t just reduce body weight and body fat, but decreased the body’s production of the IGF-1 hormone, which has been implicated in cell processes that lead to aging and disease. The study’s subjects also showed a decrease in C-reactive protein — that’s notable because it is a marker for inflammation, which in recent years has been implicated in a range of diseases, from heart disease to cancer. The results were published in Science Translational Medicine earlier this year. The Longevity Institute has funding from the National Cancer Institute. Source: Fasting: A trending food idea and new frontier in longevity science
Notes:
[2] Is growth hormone resistance/IGF-1 reduction good for you?
[5] “…and why insulin might regulate aging is poorly understood, but in mammals, the insulin/IGF signal transduction pathway regulates glucose metabolism, arguing for a link between nutrient intake and the aging process (Fig. 2). In fact, more than 60 years ago, it was discovered that reducing the caloric intake of rats could extend their mean lifespan by as much as 50%. [12] Caloric restriction also delays many degenerative changes in experimental animals, including kidney disease, [13] cancer [14] and age-associated neuronal loss in mouse models of Alzheimer’s …” …More
[7] Dairy and Its Effect on Insulin Secretion (and What It Means for Your Waistline): “…I think it’s more accurate to say that acute insulin spikes are different from chronically elevated insulin levels, especially when it comes to appetite regulation and metabolic derangement. Consider this study, whose authors gave either whey protein isolate or whey protein hydrolysate to subjects 30 minutes before a pizza meal. Subjects given whey protein isolate, but not whey protein hydrolysate, reduced post meal blood glucose and insulin levels, and ate less pizza. The whey still released insulin, but it didn’t linger for very long and it led to improved post meal numbers. It wasn’t chronically elevated. The subjects weren’t hungrier, contrary to what you might expect from someone who’d just experienced a jump in insulin. …” …More
[8] Dr. Rhonda Patrick - There is a trade off when it comes to growth hormone and IGF-1. Growth hormone and IGF-1 enhance muscle and cognitive performance but this comes at a cost: longevity. Reduced growth hormone and IGF-1 increase lifespan by increasing the expression of genes involved in stress resistance but at an expensive cost when it comes to muscles and brain. Learn all about the trade-off and ways to circumvent it. …More
[9] Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
Alecmcq
(Alec)
#13
Longo always was a salesman rather than a scientist. He has a product to sell, and therefore science takes a back seat.
Ilana_Rose
(mole person)
#14
I just happened to listen to this one yesterday. Probably the best protein centered podcast I’ve heard yet. The guy really knew his stuff and didn’t seem to have any specific biases related to protein consumption pushing him. I learned a lot.
@Dread1840 if you haven’t heard this one you might enjoy it. Episode 96, I think.
Dread1840
(Chris)
#15
I’ve listened! You know what else is funny about Layman? He’s Layne Norton’s professor and eviscerates the crap Norton spews on this show, indirectly. Great episode.
Alecmcq
(Alec)
#16
I had to look that word up. Doesn’t happen often, unless I am reading one of Bunny’s posts! 
atomicspacebunny
(Bunny)
#20
I think this is the paper (below) Dr. Layman was referring to which he states is an inadequate amount of protein?
It is not like IGF-1 & mTOR cannot be turned on and off with fasting intermittently so what does protein have to do with it?
They cherry picked the databases (“mortality”)?
This is fascinating stuff!