UBiome Vs. 23 And Me


(Banting & Yudkin & Atkins & Eadeses & Cordain & Taubes & Volek & Naiman & Bikman ) #1

Has anyone used 23&Me and or UBiome? Having found third party sites that will interpret your data for better outcomes, I wonder which would be more useful for me.

I’m still working on sleeping better, and I’m dealing with a janky left arm due to a pinched nerve, maybe (MRI scheduled), but I’m looking for my next project. UBiome plus Grace Liu’s UBiome Tree (https://thegutinstitute.com/ubiome) seems like it could produce the most actionable 30-90 day project, whereas 23&Me plus Promethease (https://www.promethease.com) has been a thing I’ve been thinking about for a while.

Anyone have experience with one or the other, or even both.


(Empress of the Unexpected) #2

The search function will reveal older threads re 23&Me.


(Eric - The patient needs to be patient!) #3

I’ve used 23 and me and found the process to be slow. Others report ancestry to be quicker. I just got the ancestry report from 23 (cheaper) and processed my raw file through https://promethease.com/ for $12.

Don’t do this if you can’t handle the results. You will likely have genes for disease states that you may never experience and some people can’t handle the worrying.


(Banting & Yudkin & Atkins & Eadeses & Cordain & Taubes & Volek & Naiman & Bikman ) #4

Thanks. I’m a project/goal oriented guy, so was wondering which might provide more projects for better results. I’m thinking the UBIOME is one or two projects then retest and maybe another set of projects. 23AndMe might be more motivating on maintenance and some insight into additional tweaks. Seems like you can dive really deep on genotype and SNPs.


(Eric - The patient needs to be patient!) #5

I’m not familiar with UBIOME and will have to research that. I discovered some things positive and potentially negative that I am making projects around.

Most if not all of the gene testing services will let you have access to the raw data file. Then you can run them through whatever SNP analysis service you want.

Prometheus has a sample report that you can look at. You can go way deep. But the sheer number of genes (SNPs) reported back, both good, uncertain and potentially bad is large and requires a strategy for you to examine and decide what is significant and what is not.

Note that the promethease report for your file can be downloaded and it works just like the demo. I really like that. I will probably run a promethease.com report every couple of years since the SNP database changes over time.

You need to consider if you inform your doctor of anything in the report. There is a general note of caution in the gene testing community about insurance companies and what they might do eventually do in terms of treatment if they know you are predisposed to certain disease states.

I talked to my PCP about this being off-the-record and she agreed. We had a verbal conversation and she also said, “don’t give me anything in writing because you want to keep this out of your medical records until at least you are on Medicare.”

So we talked a little and I did not share anything in writing. She agreed to take zero notes.

Good Luck.


(Banting & Yudkin & Atkins & Eadeses & Cordain & Taubes & Volek & Naiman & Bikman ) #6

Thanks. I’m a federal employee, so get all my insurance as parts of large groups. No exclusions and yada yada. Life insurance is also set based largely on who I was when I started 12 years ago, and then who I was when I increased the multiple a year or two ago.

And yeah, I would only informally inform my medical team. I’m working on a way to get my results anonymously.