The Secret Life of Fat Cells

(PJ) #1

Thought someone might find this interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161053/
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PJ

(Polly) #2

Thanks @RightNOW

(Choup') #3

That was a great read, thank you.

(Jane) #4

Interesting!

(Karen) #5

Sadly, most of us are leptin resistance as well. And there isn’t just a pill out there that we can take with Leptin it. Although, at one point everyone was pretty excited about that possibility.

(Mike Glasbrener) #6

Thanks for the post! Cool stuff!

(squirrel-kissing paper tamer) #7

This article made me wonder what happens to people after they scoop out fat cells and throw them into the garbage (literally, liposuction or surgery). Very interesting.

(Eric - The patient needs to be patient!) #8

Thanks. Very cool. this speaks to my slowly lowering BP with visceral fat loss.

(Bunny) #9

Interesting segment featured in cited paper:

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

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My opinion is white adipose tissue WAT can do this also if it were not for micro lipidation (ectopic fat) of skeletal muscle.

(Erin Macfarland ) #10

@atomicspacebunny once again I’d love a more layman’s explanation of the amazing science you always share!!

(Bunny) #11

Gawd I love writing about this:

Ectopic fat inside the muscle prevents the muscle from communicating or participating in how excessive glucose will disposed of once glycogen stores have been replenished and all the glucose only dependent parts of the body have had there fill of glucose. This would be an insulin resistant person.

A metabolically fit or flexible person will deplete there glycogen stores over night and be in ketosis while sleeping, this explains why they can eat more carbohydrates.

Skeletal Muscle releases a chemical hormone called aminoisobutyric acid (a thermogenin) that instructs the mitochondria around the lipid droplets to burn (oxidized to CO2) excessive glucose rather than allow it to be stored inside the adipose cell as a lipid droplet. There are two types of this chemical hormone in skeletal muscle, the alpha version and the beta version which are very specific to activating UCP-1 in both brown adipose tissue and white adipose tissue or the browning of white adipose tissue which means it is being filled with more iron rich mitochondria by neighboring adipocytes. Once UCP-1 is activated it immediately disposes excess glucose. I imagine this also causes a chain reaction in the lower UCP’s like 2, 3, 4, 5 etc.

Below I have references to the hops components of beer brewing and only using that as an example for alpha isometric-a-acids or reference point matrix so please do not go out and drink beer? …lol

So far this is the theory I’m building on but I’m not finished yet because this plugs into Dr. Doug McGuff M.D.’s work or “BODY BY SCIENCE.” Which when I look at the research intramyocellular and intrahepatic lipidation and infiltration of tryglcerides in skeletal muscle tissue; the most vulnerable part of the muscle physiology is the Gluteus Maximus to this infiltration and not only that it seems to be ground zero for the rest of the muscles to follow soon after.

Footnotes:

[1] ”…Beta-aminoisobutyric acid excretion, also called BAIB excretion, a metabolic process under simple genetic control in human beings and the higher primates, the significance of which is not fully understood. “Beta-aminoisobutyric acid (BAIB), an amino acid end product of pyrimidine metabolism, is excreted in trace quantities into the urine in almost all human beings, but the excretion of relatively large quantities of BAIB appears to be the result of a simple autosomal recessive allele. Although excretion of amino acids in the urine is frequently a symptom of a metabolic disorder, often genetic in nature, the excretion of high levels of BAIB does not appear to be deleterious, but neither is its adaptive significance yet clear. It has been observed that women excrete increased amounts of BAIB during pregnancy, an example of a nongenetic high BAIB excretion. The acid has also been found to reduce fat mass in obese mice deficient in the hormone leptin, which is secreted by fat cells and regulates food intake. The number of persons showing high levels of BAIB excretion (i.e., the frequency of the recessive allele governing the trait) has a racial distribution: Europeans, Australian Aboriginals, and Indic peoples rarely show it (fewer than 12 percent of the population); it is moderately common among Asians and American Indians (45–50 percent); and it is quite common in Melanesians (about 85 percent). …More

[2] Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity:

[3] Hop Extract, a Bittering Component Used in Beer, Helps Reduce Visceral Obesity in Healthy Overweight Adults. Abstract Background: Humulus lupulus (hops) have long been used in beer brewing for their antimicrobial and bittering properties. Hops contain alpha acids, which during the boiling process of beer, get isomerized into iso-alpha-acids also called isohumulones. Research has postulated that daily supplementation with concentrated hop extract could help to reduce visceral obesity in healthy overweight adults. The goal of this systematic review is to summarize recent research on hop extract and its role in reducing visceral obesity.

[4] Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer’s Disease.

[5] The 18+ Benefits Of Hops (Humulus Lupulus)

[6] Local man drinks only beer for 46 days, loses 44 pounds

[7] “…UCP1 is activated by long-chain fatty acids (LCFAs) that are produced within brown adipocytes by the lipolysis of cytoplasmic lipid droplets upon adrenergic stimulation of BAT (Cannon and Nedergaard, 2004). …” …More

Some illustrations for reference points:

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Here you can see how FFA’s spill over into the muscle tissue (ectopic fat).

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Where it states young/lean that is how they can eat vast amounts of carbs and not gain a pound is because they are oxidizing not storing carbohydrates. That is amazing!

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(Eric - The patient needs to be patient!) #12

And the Gluteus Maximus is not yet in my body by science routine because leg presses are for that and my left ankle is not healed enough yet. But Glycogen Depletion with BBS training seems to be a real thing.

(Choup') #13

That is so cool. I actually was reading an article on the microbiota earlier today that was explaining how drinking non-alcoholic beer was excellent for the gut bacteria, specifically because of the hop used (it was this article, sorry it’s in French).

Sur le plan intestinal, net avantage aussi pour la bière sans alcool : une flore bactérienne plus diversifiée et enrichie en bactéries bénéfiques comme les lactobacilles par exemple (remparts contre l’obésité et la résistance à l’insuline chez la souris), les Streptococcus favorables à la régulation des réactions immunitaires, et d’autres types de bactéries associées à la perte de poids chez l’homme. Un mois après le début de l’expérience, la bière sans alcool a également triplé le taux de bactéries capables de produire des polyphénols – déjà présents dans la bière, alcoolisée ou non - et des acides phénoliques comme le resvératrol, composés potentiellement bénéfiques contre le cancer, le diabète ou encore les maladies neurodégénératives.

Rough translation:
From an intestinal point of view, the non-alcoholic beer has a huge impact: a more diversified gut flora enriched in beneficial bacteria such as lactobacillas* for instance (that help against obesity and insulin resistance in mice), the Streptococcus* which help regulate immune reactions, and other bacteria linked to weight loss in humans. A month after the start of the experience, the non-alcoholic beer had tripled the number of bacteria that can produce polyphenols* - that are already present in beer, whether alcoholic or not - and of phenolic* acids such as resveratrol*, which are potentially beneficial against cancer, diabetes and some neurodegenerative diseases.

*not sure about the correct translation

(Bunny) #14

Wow that is awesome thanks for the translation I really enjoy reading about what you specifically cited in your post.

Yes, your translation is correct.

(Eric - The patient needs to be patient!) #15

Okay Bunny I assume this means you speak french. Awesome.

(Bunny) #16

After all what is google translate for …lol

(Eric - The patient needs to be patient!) #17

I once sent a question to a french software developer and used translate. He told me that my french was very good! :crazy_face:

(Choup') #18

I have to say I’m often weary about online translators because I’ve had bad surprises in the past. But they can help!

(Erin Macfarland ) #19

So taking hop extract could be beneficial :thinking:

(Bunny) #20

Bitter hops if your trying to activate brown fat but if you can get the white adipose fat doing the same through building newer muscle and changing the composition of the entire skeletal muscle to a more lean state through weight lifting and resistance training.

You are a pretty muscular gal so I don’t see a problem in that area…lol