It’s here:
It’s split into Dave for the analysis of a study that just came out about LMHR (lean mass hyper-responders) and LDL (Danger! Deadly! Little BBs that attack arterial walls!). Dr. Bret Scher then interviews Nick Norwitz, though it’s more about how Nick is dealing with being at medical school and producing papers that go against conventional thinking (ie., LDL = death, carbs can lower LDL in LMHRs).
If you listen from about the 26 minute mark, Dave’s talk gets really interesting. They have more data on Lp(a) and ApoB, both of which are the evil lipids du jour. That will be coming out in a future paper.
They are also going to use AI to perform a better calculation of calcification, and Dave was saying that everyone has calcification to some extent.
The most interesting – to me – thing Dave says is that they have data about the actual makeup of LDL. What his theory appears to be is that for the same particle size, the makeup of the LDL particles is different between LMHRs and the other folks they were looking at.
If true, this would turn the whole LDL theory on its head.
And, it makes the most sense to me. As a believer that LDL does not matter, I’ve never been fond of the particle size theory. If LDL does not matter, the size of LDL does not matter. Or at least that’s my theory.
I can see that damaged LDL might matter, like LDL that has been oxidized by polyunsaturated fat. That might be important.
Along these lines, if the LDL particles themselves are different for the same size, that might make sense too.
I still think something else CAUSES the damage that LDL seeks to repair. But if changes in LDL mean that the repair is affected, I could see how that could be important.
Anyway, it’s a useful 45 minutes or so.