The Complexity of Fat Cells


(Bob M) #22

At some point, I’ll have to print this out and read it in detail. They find differences in obese versus non-obese, but this brings up the age-old conundrum that you can’t tell causation. Do people get obese because their fat cells are different, or does getting obese cause their fat cells to become different?

And this might explain why some experience benefits eating saturated fat, whereas I don’t. I can eat as much butter as I want, with no effect (other than weight gain). Zero satiety. Same with other high-saturated-fat products such as cream cheese. Just cause weight gain.

(PJ) #23

One of the few predictable things for me food-wise is that a high PUFA meal will make me feel somewhat crappy and hungry not long later, while a high SFA meal will make me feel ok and full for hours. So clearly it does differ between people.

It was always this way for me, I simply did not become aware of what factor made the difference until I started reading on the two. Prior to that, I thought it was more like mayo vs butter effects. Always wondered why a high mayo dish was diff than say, a high sour cream dish, and I’ve sometimes made the same dish with those different things. I like mayo much better in most things but the body result isn’t better. I was attributing it to soy in the mayo but since then my identification of PUFA in food improved. Paying attention to the topic helped me nail it down to be more specific.

But I expect someone lipedemic and super morbidly obese has plenty going on that most people don’t. Whatever it might be. Which as you point out… could be a result, not a cause, or some concomitant buried in the middle, who knows.

(Bob M) #24

I have seen others say something similar about high-PUFA meals (even chicken/pork). I definitely think there’s a difference in folks in this, as I don’t get the same effect. I can eat high PUFA and get no extra hunger, or eat high sat fat, and get no extra satiety.

Now, whether it’s based on this idea of fat cells or something else, I’m not sure. But it seems reasonable this could provide the missing evidence. It’d be interesting to find someone who does well on a high saturated fat diet and me (who does not do well) and perform these same tests on fat for both. Preferably with someone who is still overweight (as I am), to minimize differences.

I do have a genetic test coming, and there’s one test indicating whether or not you tend to get fat on a high sat fat diet. Unfortunately, this is correlation (and from crapidemiology too), not causation, but it’ll be interesting to see what I have there.

Edit: Forgot to say that the thing that does provide satiety for me is high protein. I can eat high protein, low fat keto meals, or even with a few carbs at times, and be completely sated for hours. As in 8+ hours.


There are no meal with the power of satiating me for 8+ hours but less than a day… I get hungry in a few hours or I will be fine for a day.
I can write my satiation things again, it’s simple: chicken and added fat never works. Pork, beef, eggs are great for satiation but I still need a decent amount of food, often even per meal but definitely per day. Dairy either don’t satiate me or I don’t know about it, the amount I used wasn’t much and now it’s zero as I want to consume only satiating food and only items my body is very fine with, even in bigger quantities.
I still can’t test lower-fat than 60%, it’s hard to get the right food for it, it gives me bad macros (my protein is high enough without that but I can’t raise it super high anyway so I just end up starving a bit) and I start to crave fat.

Surely there are personal differences, I see that in the carnivore threads. It’s easier to see there as many people just eat meat and maybe some fat with it so other items don’t interfere.