Yes, that’s the biggest one it seems, but not the only one. I think Brad’s target audience was partly the number of people who don’t lose further weight despite being ketogenic, reasonable cals. Insulin is not their issue. Keto solves the insulin issue.
The idea is the supplements that up AMPK and ppar-alpha and reduce SCD1 and other things, combined with high SFA and low PUFA, might slowly but gradually solve the “too much pufa constantly in bloodstream circulation, leading to insufficient ROS to use as signalling molecules to make individual adipose cells resistant {hence keeping the fat in circulation longer (satiety)} (and some other things)}” and so indirectly (kinda by adipose cell content PUFA-attrition {FA type ratio% change} then, the leptin issue.
If keto worked indefinitely for everybody to lose all the fat they needed to lose this might never have come up. It does not, probably because a lifetime of poor nutrition has a variety of effects on people, and keto mostly whole foods diet can solve most of those, but possibly not all of them.