Peter Attia podcast Rick Johnson Salt, BP, Fructose, uric acid, metabolic syndrome


(Eric - The patient needs to be patient!) #1

Wow, this one is really interesting. Salt does play a role in essential hypertension but not in terms of quantity of salt but instead the concentration that the kidney’s see.

Drink water before eating a salty dish. High salt concentrations inflame the kidneys which then produce uric acid and generate fructose (who knew?) and raise BP.

Lots of conversation on Fructose (ingested and generated in the body) on diabetes and related.

I’m going to have to listen to this one again.


(Utility Muffin Research Kitchen) #2

I’m 1h into the podcast and it’s certainly interesting, but I think Johnson focuses very much on issue and sees only part of the picture. For example he talks about fructose driving up uric acid, and then gives allopurinol which blocks the conversion of purines into uric acid and has nothing to do with fructose. Huh?

Also there are certainly other ways how uric acid is produced. n=1, but my uric acid went up when I got on a ketogenic diet (with moderate meat, probably as much meat as before). I suspect that I’m oxalate sensitive, the next blood test in a month will tell if restricting oxalates lowered my uric acid levels.

And he completely misses the connection between metabolic syndrome and salt elimination, at least he doesn’t talk about it where it should have come up.