So-called ‘fat adaptation’ really means metabolic flexibility. We never lose the ability to metabolize glucose, although glucose metabolism can and does get messed up in many folks and causes most of the negative metabolic issues currently rampant in the general population.
What you’re asking, though, is once metabolic flexibility extends to fats/ketones again - keep in mind you had it as a prenatal and infant until weaning from mom’s milk - can you ‘lose it’ again. The answer is yes, you can. If you don’t remain consistently in ketosis your cell mitochondria will once again lose their ability to metabolize fats and ketones. If you’re constantly eating mostly glucose in the form of carbs, then why would your cells maintain flexibility? How long it takes to lose metabolic flexibility is very likely an individual thing. But if you’re constantly in/out of ketosis, then your metabolic flexibility to metabolize fats and ketones remains relatively inefficient even if you have it. If you’re mostly in ketosis and only once in a while out, then it’s more stable - but, still, it’s way better to stay consistently in ketosis than not. Ketones are good stuff in and of themselves healthwise. Carbs and glucose not so much. Glucose is only necessary for those few cells that don’t contain mitochondria. It takes a very small amount of glucose to maintain those cells. Flooding yourself with ingested glucose in the form of carbs upsets everything.
PS: I just edited this a bit to replace ‘carbs’ with ‘glucose’. Because metabolic flexibility is about glucose. ‘Carbs’ are just another word for glucose. Humans evolved eating fat and meat and generating glucose from gluconeogenesis - not eating it. Lots of folks mistakenly think 'metabolic flexibility is about what’s on your plate, and it’s not. It’s about what your cells are converting to energy.