My Methylation Profile

#1

I submitted my DNA to 23andme a couple years back. I got the following back with respect to my Methylation Profile.

So I gather I can process folic acid fine and don’t need methylfolate but shoudl be using methyl-b12 lozenges a couple times per day?

Is this stuff just pseudoscience? What do you make of the following? Do I need to get a real test from a doctor who specializes in this? Perhaps they test for other things 23andme didn’t test for?

I have the VDR Taq / Bsm genetic flaw as well… but I don’t know what this means really… I do take vit d supplements because my baseline is below normal… last i checked 25 D hydroxy was 54 – 17 previously.

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#2

Also found my ApoE was e2/e4 – not the very desirable e3/e3 whatsoever! I know I must of gotten the e4 from my dad’s side because dementia runs on that side of family not my moms. Also my mom was morbidly obese all her life and type 2 diabetic… so def got the e2 from her – my dad was a twig his entire life and no diabetes on his side of family.

I don’t know what it makes me! Probably especially likely to get dementia i dunno. I am eating keto though at least! Maybe by doing that the e2/e4 can no longer express itself to do further damage.

(Bunny) #3

I personally think nutrigenomics is useful if your having problems for example with burning body fat or your a hyper-responder.

It just shows you what is less likely and more likely good or bad for you, but I don’t think it is absolute.

I think Glutathione deficiencies and levels of endogenous production in the liver have more to do with it then going after the middle-man?

Nutrigenomics to me is based more on how close or far your ancestors lived to the equator?

#4

Bunny, I was looking into glutathione supplementations last week and came across a few studies showing that oral supplements are very weakly absorbed, sublingual application is best. I decided to increase histamine-intolerace safe veggies with higher glutathione content. What do you think?

(Bunny) #5

What really helps boost endogenous glutathione levels is milk thistle.

#6

Milk thistle is very high in oxalates :frowning:

(Bunny) #7

Drink lemon water (citrate) to dissolve oxalates (degradation) and you may be resistant to oxalates anyway if you have enough oxalobacter formigenes “O” in your gut bacteria or you have genetic susceptibility (hyperoxaluria) just drink lemon water, why people are so resistant to drinking lemon water or eating lemons occasionally defies logic?

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Just like with trying to avoid lectins; you would starve to death trying to avoid oxalates. Or become severely malnutritioned?

Broad spectrum antibiotics like Quinilone used to treat live-stock or prescription anti-biotics destroy “O” in the human gut.

You eat bone broth (high in glutathione) or meat (hydroxyproline) with out lemons and you have a hyperoxaluria genotype then the bone broth (hydroxyproline) or collagen in meat can turn into oxalates as you can see in the image below?

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References:

[1] Oxalobacter formigenes and its role in oxalate metabolism in the human gut

[2] Oxalate synthesis, transport and the hyperoxaluric syndromes.

#8

I have to stay away from citrus due to my histamine-intolerance…but my symptoms are very light and very rare since going keto, so maybe I should try adding lemon juice and see what happens.

Thanks bunny :slight_smile:

(Eric - The patient needs to be patient!) #9

Jennifer

I’m a e3/e4. e2 is fairly rare. My understanding is keto (strict) helps reduce the risk of AD. There is conflicting information on the value/harm of saturated fat. Amy Berger says that hunter-gatherer tribes with a preponderance of e4 demonstrate that there is a genetic advantage (natural selection) to E4s that eat sat fat.

The Alzheimer’s Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer’… https://www.amazon.com/dp/1603587098/ref=cm_sw_r_tw_dp_U_x_mFr3DbC6N0B1S

This site is for people with 1 or more e4 https://www.apoe4.info/wp/

The forum is very busy.

For now, I’m focusing on:

  • less stress
  • better sleep
  • more lean muscle mass (resistance to failure training)
  • less body fat
  • very strict keto (most days <10g / day) - some days carnivore
  • Omega 3 sources of protein as often as possible
    • sardines
    • kippers
    • salmon
    • smoked mackerel
  • Vit K2 from fermented vegtables (mostly active culture sourkraut)

When I hit maintenance weight I might change my strategy but near term I’m just improving health and being ketogenic.

I don’t know if this is a good strategy or not but my rationale is near term health first then longer-term health.

#10

So if you guys had my methyl profile, would you be supplementing with 1000-2000 mcg of Methyl-B12? I read that’s what one should do with the MTRR A66G mutation.