Mtor

fasting
(Free Hearsay) #1

So I have been reading about the keto and basically wondering if Mtor is permanently inactivated and autophagy is established how can new cells be produced ? Is it not the case that carbs need introducing so as to activate Mtor so the body can manufacture new cells.If this is so,is it not dangerous to continually be in ketosis?

(Doug) #2

mTOR responds to protein - it perks right up when sensing ingested protein and slows down or stops autophagy. No worries about ‘permanent deactivation’ as far as I know. And for mitotic cells - the type that can divide and multiply - I don’t think autophagy stops them from doing it in the first place.

(Free Hearsay) #3

Sorry OldDoug.I thought Mtor was inhibited by lack of total nutrition no matter what macro.Also I did not explain properly regards mitosis.What I meant was -when Mtor is shutdown is there not a slowing down of cell division due to the priority of the pathway which is to generate energy by autophagy?

(Free Hearsay) #4

Reason for my question is I am thinking that introducing carb cycling to my diet rather than permanently being in ketosis.
Whereby I fast -Autophagy Then carb cycle -maintain and assist mitosis.

(Doug) #5

If you don’t need/want to be in ketosis for metabolic reasons - weight loss, better hormonal regulation, etc. (why do you want it in the first place?), then carb-cycling may not be bad. However, I’ve never seen anything to the effect that autophagy or ketosis prevents cell division or cell growth. Autophagy consumes damaged cellular components, “old” stuff - faulty protein structures, etc. People have fasted for months, even more than a year, and the essential cellular processes and growth continue.

(You've tried everything else; why not try bacon?) #6

There is always a certain amount of autophagy going on in any case, depending on how you define it. All proteins have a lifespan—of mere minutes, in some cases—so there are always proteins being disassembled for their amino acids. Furthermore, a minimum quantity of amino acids is always being broken down, and the nitrogen from them is excreted. The nitrogen lost from this breakdown of amino acids must be replenished, which is one of the reasons protein is required in the diet.

There is no need for any carbohydrate in the diet. There is not a single known carbohydrate-deficiency disease, and the liver is perfectly capable of making enough glucose from the protein we eat, to supply all the cells in the body that have to have it (such as our red blood cells). If you want to eat carbohydrate, go ahead, but you have no need of if for any purpose.