Klotho

(Karen) #1

Question: have you heard of Klotho protein. Increased amounts are supposed to help with CKD. I read that a keto diet decreases Klotho.

(You've tried everything else; why not try bacon?) #2

Interesting name. Klotho, along with her sisters Lachesis and Atropos, were the three Fates of the Greek pantheon. One of them spun the thread of each human life, another measured it out, and the third snipped it. Unfortunately, I couldn’t tell you which was which.

(Karen) #3

True and what a great name for this "lonvgevity " protein. The part that interested me though was:

Protects Against Kidney Diseases
Klotho regulates calcium homeostasis in the blood and mainly the kidneys. R R
Upregulation of klotho may prevent fibrosis in the kidneys. R
Klotho may also improve electrolyte imbalances and abnormal amounts of proteins in the blood. R R

I have kidney issues. So what concerns me is:
What Reduces Klotho?
Adiponectin R
Angiotensin II activation R
Asbestos R
Doxorubicin R
Estrogen R
Hmgb1 activation R
Hypervitaminosis R
Ketogenic Diet R
Nephrectomy R
NMDA Inhibition R
Stress and Depression R
Timp-3 Inhibition R
TGFβ R