The dose used in https://www.tandfonline.com/doi/full/10.1080/27697061.2022.2117743 is higher than that of KetoneAid (one 12.5g dose is half a KetoneAid bottle, but only 1 of 12 scoops in Metabolic Switch). And Eric Verdin himself is an extremely legit scientist (head of the Buck Institute and has lots of wonderful interviews)
BHB + MCTs = METABOLIC SWITCH®
The idea of recapitulating the beneficial effects of ketogenic diets by simply ingesting the ketone BHB might sound like an “elixir of life” dreamed about by biohackers looking to use technology to optimize lifespan. But science has made such a product possible.
Juvenescence, along with Drs. Verdin and Newman at the Buck Institute of Aging, partnered to create “Metabolic Switch®”, a C6 Ketone Di-ester which may provide the beneficial metabolic effects of ketosis with the healthy-aging effects of BHB.
When Verdin first “synthesized” the idea for the product to John Newman, the “flash of brilliance” was immediately apparent — a C6 Ketone Di-ester would allow a “hybrid” of endogenous and exogenous ketosis in the body. Current commercially-available ketone drinks work by raising levels of BHB in the body rapidly by detaching a molecule of BHB from another molecule called butanediol.7 What makes “Metabolic Switch®” unique is that once consumed, it’s broken down in the body into butanediol and a medium-chain fatty acid (also known as medium-chain triglycerides or MCTs) called caproic acid, or C6.