H,Pylori, why treated with PPI and antibiotics


(Omar) #1

I understand the antibiotics part, but why PPI?

fact 1:
H.pylori likes low gastric acid

fact 2
PPI reduce gastric acid secretion

:roll_eyes:


(Doug) #2

Omar. Hello old friend. It’s been a while. :slightly_smiling_face:

I don’t know about it “liking” low acid, but it does act differently over the pH range. “Low pH” is one thing, while “low acid” is the opposite - higher pH.

In a more acid environment, H. pylori is resistant to antibiotics. So, to make the antibiotics effective, the pH needs to be raised, made less acidic.

Our stomachs are usually at a pH of 1.5 to 3.5, very acidic. Below a pH of 6, H. pylori is in its ‘coccoid form’ where it doesn’t replicate or multiply, does not ‘grow,’ but it can survive in very harsh conditions in that form.

Above a pH of 6 is where it replicates, but that’s also where antibiotics can kill it. So, stopping the stomach from secreting as much acid is part of the treatment - necessary for antibiotics to work.


(Omar) #3

Very informative reply

Glad to get a welcome from you Doug


(Omar) #4

The doctor performed upper endoscopy

The nurse said no H.Pylori, and gave me 2 prescription, a PPI and calcium blocker

But there are findings
1-Esophagus
Linear erythema of the lower segment, partiality incompetent cardia, and reflux of the gastric

2-Stomach
Diffuse erythema involving the whole gastric mucosa especially, the antrum. On retroversion, Stigmata of sliding hiatus hernia about 1 cm width X 2cm length

3-Pylorus
Round, regular and reactive

4-Duodenum
Marked Bulbitis

I did not see the doctor yet. But the nurse said no H.Pylori.

Not sure I understand the report, because I dont have GERD. But I have pain in the esophagus. Kind of lack of comfort rather than pain.

scary words
Diffuse, incompetent cardia, Stigmata of sliding hiatus hernia

I will ask him next appointment


(John Bradshaw) #5

Thx Doug! Great explanation.


(Bob M) #6

I can honestly say that I have no idea what most of that means.


(Omar) #7

thanks

I will post after seeing the doctor later this month.