Glycine supplementation re: lastest podcast

stefanilinn · 2018-02-07 15:22:14 UTC

Why the Creatine ? How much Creatine ?

Ketobrewer · 2018-02-07 16:25:53 UTC

I’m pretty sure @richard said he was having a teaspoon (about 5 g) with his coffee, so not spread out during the day, but only once per day.

andy71 · 2018-02-07 22:31:40 UTC

Some science…

ncbi.nlm.nih.gov

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice.

MK Caldow, DJ Ham, DP Godeassi, A Chee, GS Lynch and R Koopman, Clinical nutrition (Edinburgh, Scotland), 2016 10

Calorie restriction (CR) reduces co-morbidities associated with obesity, but also reduces lean mass thereby predisposing people to weight regain. Since we demonstrated that glycine supplementation can reduce inflammation and muscle wasting, we hypothesized that glycine supplementation during CR would preserve muscle mass in mice.High-fat fed male C57BL/6 mice underwent 20 days CR (40% reduced calories) supplemented with glycine (1 g/kg/day; n = 15, GLY) or l-alanine (n = 15, ALA). Body composition and glucose tolerance were assessed and hindlimb skeletal muscles and epididymal fat were collected.Eight weeks of a high-fat diet (HFD) induced obesity and glucose intolerance. CR caused rapid weight loss (ALA: 20%, GLY: 21%, P < 0.01), reduced whole-body fat mass (ALA: 41%, GLY: 49% P < 0.01), and restored glucose tolerance to control values in ALA and GLY groups. GLY treated mice lost more whole-body fat mass (14%, p < 0.05) and epididymal fat mass (26%, P < 0.05), less lean mass (27%, P < 0.05), and had better preserved quadriceps muscle mass (4%, P < 0.01) than ALA treated mice after 20 d CR. Compared to the HFD group, pro-inflammatory genes were lower (P < 0.05), metabolic genes higher (P < 0.05) and S6 protein phosphorylation lower after CR, but not different between ALA and GLY groups. There were significant correlations between %initial fat mass (pre CR) and the mRNA expression of genes involved in inflammation (r = 0.51 to 0.68, P < 0.05), protein breakdown (r = -0.66 to -0.37, P < 0.05) and metabolism (r = -0.59 to -0.47, P < 0.05) after CR.Taken together, these findings suggest that glycine supplementation during CR may be beneficial for preserving muscle mass and stimulating loss of adipose tissue.

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice.

KetoLikeaLady · 2018-02-07 22:36:31 UTC

This is super interesting!!!

Emacfarland · 2018-02-07 23:17:28 UTC

I wonder what the equivalent dose is in humans?

richard · 2018-04-08 15:02:10 UTC

I’ve been adding a tsp of L-Carnitine (edit I initially type Creatine … that was a typo) every day to a small ramekin of berries … it’s sour, but I’m now used to it.

Why? Because Tommy Wood challenged me to try it.

My Methylation is under pressure thanks to my MTHFR status., I am heterozygous for C677T which means my methylation is 65% as efficient as someone who is CC, but at least I’m not a TT which would be 30% as efficient.

ncbi.nlm.nih.gov

Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study.

M Petr, M Steffl and E Kohlíková, Physiological research, 2013

Creatine (Cr) is recommended as a dietary supplement especially for athletes but its therapeutic potential is also discussed. It is assumed that human body uses Cr for the formation of phosphocreatine, which is necessary for muscular work as a source of energy. Production of Cr in a body is closely connected to methionine cycle where guanidinoacetate (GAA) is in a final step methylated from S-adenosylmethionine (SAM). Increased availability of SAM for phosphatidylcholine (PC) and sarcosine synthesis can potentially stimulate endogenous production of betaine a thus methylation of homocysteine (HCy) to form methionine. Our subject who was methylenetetrahydrofolate reductase (MTHFR) 677TT homozygote lowered plasma HCy from 33.3 micromol/l to 17.1 micromol/l following one-month Cr supplementation (5 g/day) opposite to 677CC and CT genotypes whose HCy levels tended to increase (but still in normal ranges). We suppose that Cr supplementation stimulates pathways leading to production of sarcosine which can serve to regenerate tetrahydrofolate (THF) to form 5,10-methylene-THF. This could potentially increase MTHFR enzyme activity which may later result in increased HCy methylation. Cr supplementation significantly effects metabolism of one carbon unit and potentially lower body´s demands for methyl groups. This could be beneficial as in the case of reduced enzyme activity such as MTHFR 677C/T polymorphism.

Charlz · 2018-02-08 03:12:45 UTC

So … what dish are you going to ‘torque’ test that tooth on? Start with Sou Vide pork belly and work your way up to Old Papa John’s Boot Strap Jerky?

richard · 2018-02-08 05:42:05 UTC

Well Imma let the periodont yank on it cos if he breaks it he’s gotta go back in and fix it.

Charlz · 2018-02-08 06:42:59 UTC

Carlina · 2018-02-11 04:06:20 UTC

hi Richard, can you clarify the dosage for glycine (as I heard once per day in your coffee) and what brand (for Australia)
Pretty please?

Vega · 2018-02-11 20:25:09 UTC

I acquired some glycine yesterday to give this a try.

gettingthere · 2018-02-13 14:04:34 UTC

I also heard this podcast and went out to buy glycine - mainly for the sleep effect it is supposed to promote.
I have been on it for 4 days or so. I do seem to have had a better sleep pattern (according to my Fitbit - although not in the Deep Sleep area as other comments - but in the Light Sleep).
Seems positive and am watching this space!1

richard · 2018-02-14 05:45:05 UTC

I use

I have a teaspoon in coffee in the morning.

Patti2008 · 2018-02-14 17:57:34 UTC

Curious why you use glycine rather then a collagen supplement?

richard · 2018-02-14 18:48:10 UTC

Producing Glycine is the part of collagen manufacture that might be the rate limit for people with my methylation status. But it was also the first thing I saw in the store, so I decided to give it a try.

Lorianix · 2018-02-15 00:41:55 UTC

I bought 1kg of Glycine after listening to this podcast Then I joined this forum and have been following this thread with interest. I track my blood ketones and they have consistently stuck around 0.3 - 0.4 since December, so I’ve been keen to see higher numbers. Anyway, I watched the youtube vid posted earlier in this thread on the day I started my glycine. I watched it, facepalmed, went stuff it! I have 1 kg to hoe through so I’ll experiment on myself. The first 3 days my ketones went lower - 0.1, then they shot up and now I’m consistently seeing 0.7 - 0.9 every day after. I’m pretty stoked. Is this how it’s happened for you guys or did you see the higher numbers straight away? Also I wonder if the guy in the video would have seen higher numbers if he’d stuck with it for a few more days. I’ve been taking mine right before bed btw

dub · 2018-02-16 17:37:15 UTC

I had an acute knee injury (tendonitis) from sprinting that was pretty painful. I’ve been taking glycine for a week and it has healed rapidly. Suspect it’s helping with Collagen regrowth.
Other subjective impressions: sleeping better, better hair and skin, feel a lot more “solid” and muscular.

Lueloff · 2018-02-24 21:52:04 UTC

How does one know they have this mutation?

Primal123 · 2018-02-25 02:33:46 UTC

Genetic testing.

Andy_Rubie · 2018-02-25 21:51:41 UTC

His video experiment is wildly unscientific and he jumps to strong conclusions without thinking them through. Glycine supplementation increases my ketone levels alot. Consistently.