Gluconeogenesis information

collaroygal · 2017-07-30 00:24:32 UTC

For deeper science about this:

carolT · 2017-07-30 09:23:38 UTC

Some other reading material, for those who are T2D or insulin resistant.

ncbi.nlm.nih.gov

Regulation of hepatic glucose metabolism in health and disease.

MC Petersen, DF Vatner and GI Shulman, Nature reviews. Endocrinology, Oct 2017

The liver is crucial for the maintenance of normal glucose homeostasis - it produces glucose during fasting and stores glucose postprandially. However, these hepatic processes are dysregulated in type 1 and type 2 diabetes mellitus, and this imbalance contributes to hyperglycaemia in the fasted and postprandial states. Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this Review, we discuss the in vivo regulation of these hepatic glucose fluxes. In particular, we highlight the importance of indirect (extrahepatic) control of hepatic gluconeogenesis and direct (hepatic) control of hepatic glycogen metabolism. We also propose a mechanism for the progression of subclinical hepatic insulin resistance to overt fasting hyperglycaemia in type 2 diabetes mellitus. Insights into the control of hepatic gluconeogenesis by metformin and insulin and into the role of lipid-induced hepatic insulin resistance in modifying gluconeogenic and net hepatic glycogen synthetic flux are also discussed. Finally, we consider the therapeutic potential of strategies that target hepatosteatosis, hyperglucagonaemia and adipose lipolysis.

jamestorie · 2017-07-30 10:40:52 UTC

Wow, that first article was great! And long, but worth the read. Definitely not more than I ever wanted to know! I soak up info like a sponge! Now if I could only afford to go back to school!

Shalmar · 2017-07-30 13:43:24 UTC

Interesting write up in layman terms by Amy Berger- worth a read

OldDoug · 2017-07-30 15:19:24 UTC

James, totally agree - this stuff is fascinating! A couple days ago I was “zoning out” going across Interstate 70 in eastern Colorado, thinking about what I’d do if my job vanished, and one possibility is returning to school (although being age 58 greatly affects things). Biochemistry and finding out how “things work” in greater depth is what I came up with.

jamestorie · 2017-07-30 16:07:36 UTC

I agree! Due to life happening, I never got to finish college. Maybe I’ll get the chance when my kids make it through!

jamestorie · 2017-07-30 16:07:51 UTC

I’m with you there! Maybe I’ll get the chance to finish college when my kids get through!

Tovan_Nhsh · 2017-07-30 16:20:56 UTC

Thanks for the links, I really enjoyed the first article.

Jason_Fletcher · 2017-07-31 18:48:29 UTC

You are getting a better education on this forum then most people will ever be able to get from a college. Why pay someone to tell you what to think?