Hi all, longtime ketoer.
Been prescribed doxyclicine for acne. I stumbled upon this post, and wondered if it is true that doxycycline will kick me out of ketosis.
Here is the post:
“Greetings, I am a scientist on the ketogenic diet that is very relevant to your research. Since I measure beta hydroxybutyrate (blood strips) and also urine ketone strips for the level of my ketosis, I found that the moment I took Doxycycline I was kicked out of ketosis. Then about 6-8 hours later my ketosis starts to return and the moment I take thenext dose of the Doxycycline I am out of ketosis again. This confirms (as a 1-person study) that Doxycycline is using insulin receptors. That is because it backs the glucose up that the liver puts into the blood for the parts of the brain that need glucose (corneas and iris I believe). When that much glucose is in the blood, and insulin is taken up by something else, beta hydroxybutyrate and ketones are dumped (in a healthy body) immediately. When a medicine uses the insulin, my urine suddenly shows ketones at near keto acidosis level and the blood test shows I am not in ketosis. If my insulin receptors are tied up with the drug, my glucose waits in the blood until it can be picked up. Prednisone caused the biggest increase so far in glucose backing up to 180 mmol/L using a Bayer Contour measuring device!! In ketosis my blood sugar is between 62 to 90–it may go to 110 after a heavy workout while fasting–that is all from glycogen from the liver. In nutritional ketosis having blood sugar in the 60s is normal. I believe that my finding, though only one person’s findings, can help you understand the pharmacology behind why Doxycycline may cause insulin sensitivity and confirms that it does if taken long enough and/or often.”
I don’t have Stix or blood testing strips, so although I’d like to test this myself I cannot.
Does anyone have experience with doxyclicine and can confirm or deny this?
I’ve also read elsewhere that doxycycline reduces insulin resistance, is this something one would want while maintaining ketosis? I’ve always been of the mindset that insulin resistance is a negative.
Hopefully someone can clear this up - thanks all.
Edit: found this as well,
“Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance. Doxycycline (DOX) is a potent MMP inhibitor. We hypothesize that DOX will enhance insulin sensitivity and decreases inflammation in obese participants with type 2 diabetes (DM2)”