I listened to about 3/4 of the Sodfather’s podcast, then listed to both of the Gary Taubes ones. I’ve always thought that Taubes had a great view of how science should be done. For instance, he says (and this is based on many others) that once you decide a certain path is the correct one, you’re done. You see everything through the lens of that path.
He gave the example of a paper he liked about genetics and obesity. He read the paper and thought that it had evidence of his ideas (fuel partitioning causes obesity), and he gave it to someone to read. That person believed that CICO (calories in, calories out) caused obesity, read the same article, and got nothing out of it about fuel partitioning. Gary said he was stunned, but then said he realizes that once you choose a belief system, it affects everything you do and read.
They did get sidetracked a few times to lipids, familial hypercholesterolemia (FH, a genetic disorder causes high LDL, etc. (My own belief: LDL is not causal for atherosclerosis; something else is causal, but LDL is associated with the damage caused by whatever the causal thing is, which could be oxidized or damaged LDL, and a whole host of other items. But LDL and FH are complex.)
I think Gary brought up quite a few ideas of how to test his theory of fuel partitioning (basically, some people put calories into fat, some don’t, and the amount of calories could be immaterial – a person could become obese eating a lot fewer calories than a person who never becomes obese). They sounded good to me, but once you believe everything is calories, they don’t make sense to those folks.