Current thinking: Covid-19 = endothelial damage

(Bob M) #1

It appears covid-19 is killing people by starting with endothelial damage. The endothelium is a thin (supposedly one cell thick) layer that protects the arteries (among other things). On top of that layer is the glycocalyx, which looks like super fine hairs. Yes, that’s different from every drawing of arteries you’ve ever seen, because they are wrong.

Anyway, Malcolm Kendick’s theory of heart disease is that you have to protect the endothelium. Anything that detrimentally affects the endothelium, such as sickle cell disease, pollution, stress, etc., causes heart disease. Anything that protects the endothelium, such as sunshine (increases NO, nitric oxide), Viagra (causes NO to be “released” into the blood stream), etc., prevents heart disease.

Damage to the endothelium also makes sense, because it fits in with Kawasaki disease, which some children are getting and which causes damage to the endothelium (or, in this case, the other way around).

Here is Dr. Kendrick on the current thinking:

And here are additional articles/studies in this vein:

This is likely why some people are getting delayed symptoms (up to 56 days later), because once you damage the endothelium, it’s like instant heart disease.

We also know of a person in his early 60s (we think, anyway), who got covid-19 and was in the hospital about a week. He recovered, but his doctors have estimated he has a 20% permanent loss of function in his lungs and heart. (Unfortunately, his 93 year old mother died of covid, and she gave it to him.) If he got endothelial damage during his sickness, that would make sense.

Does anyone know anybody who has been keto & died from Covid-19?
(Jane) #2

Can damage to the endothelial layer be repaired?

(Full Metal KETO AF) #3

Interesting Bob, I heard this a couple of days ago and the gears started grinding. I’m fairly certain that I had COVID in Jan-Feb and towards the end of February a couple of weeks after I got a massive blood clot that cut off circulation to my leg. I had to get bypass revision to a 20 year old artery bypass suddenly. J was already wondering if there was a connection. :cowboy_hat_face:

(Karen) #4

It would be interesting to see if you got an antibody test if you actually have had it. I think a lot of people had it way back in January and February

(Bob M) #5

@Janie That is a very good question. I assume the answer is “yes”, as the endothelium/glycocalyx is always getting damaged and repaired in “real life”. I believe it’s when the rate of damage > rate of repair that’s the issue. Maybe you can turn it around? I don’t see why not.

I would assume things like vitamin C, vitamin D, vitamin k2, magnesium, low excursions of blood sugar, etc., would all help. And even things like taking ACE inhibitors (increase NO) or Viagra (increase NO) would help, though I’m not big on taking drugs if you don’t have to. I even really don’t like to recommend vitamins, though even I’m rethinking that and do take D daily, magnesium sometimes (used to take a ton; less now), and k2 sometimes. I can’t tell where I like Vitamin C or not, though that may be due to the actual pills I try.

And, also, I may have misspoke about the person we know. Once the cascade starts (with endothelium damage), there is a lot that occurs during the cascade. So, his issues might be due to those other elements, too.

@David_Stilley That seems plausible. Let us know if you get an antibody test.

I don’t think anyone knows how badly people get affected by covid. Of course, those who end up in the hospital or – heaven forbid – die obviously were affected badly. But what about those who got it but just got cold/flu/lack of smell/temperature? How “damaged” do they get? If at all? No one knows, or possibly could know until later, if endothelial function say really was affected. If you get a small dose of that, maybe you don’t know for years?

I have heard too that there are about 4,000 studies per WEEK being produced on covid-19. That means no one can keep up with the volume of info.

(Cristian Lopez) #6

Imagine if we all started popping the blue pill to prevent endothelial damage from Covid-19


Viral infections naturally lead to vasoconstriction. I’ve noticed that taking Vitamin K2 was overclotting my A+ blood but it may not do the same in other blood types. Eating foods with K1 didn’t cause an issue.

The best defense in those vulnerable is Vitamins in conjunction of sunshine and bodyweight exercises to increase NO production and stimulate the immune system. Such as full squats while holding onto a counter, bench dips and occasionally push ups. Long walks and sleeping with the window open is another must.

I can’t tolerate synthetic Vitamin C either because of the oxidized vitamin C impurities. I take Vitamin C from Acerola.

(Jane) #8

I bleed profusely if I don’t supplement K2

(Jane) #9

I cannot even blow my nose during extreme allergy season w/o a bloody nose unless I supplement with K2

(Jane) #10

It is scary to not be able to stop a nosebleed after blowing your nose.

(Michael - When reality fails to meet expectations, the problem is not reality.) #11

(Bunny) #12

The Endothelium interacts with Vitamin C which is kind of neat when you think about it because Vitamin C travels along the Endothelium like a snake as the Endothelium grabs the Vitamin C and makes Type IV collagen out of it to make itself stronger (resistant to damage) and more slippery.

Not enough Vitamin C and you get (“permanent”) damage?

12 Foods With More Vitamin C Than Oranges

Proanthocyanidins (e.g. grape seed extract, pine bark extract etc.) do the same-thing but much better than Vitamin C on the Endothelium which upregulates the endothelium with nitric oxide synthase to produce NO. Makes veins and arteries super strong and relaxes vaseoconstriction.

(Ellenor Bjornsdottir (spare me thy resistant starch spiel)) #13

That may be less than reliable for Full Metal’s circumstances because, unless I’m mistaken, he is on medical immunosuppression, which blunts the immune response that would create antibodies.