Interesting how caloric restriction impacts certain genotypes in a single based pair nucleotide polymorphism (SNP’s) DNA sequence expression in contrast to longevity and “BMI risk of death:”
16 Biomarkers May Predict Human Lifespan - GEN Genetic Engineering & Biotechnology:
“…The SIB team found that most SNPs influenced lifespan by impacting more than a single disease or risk factor—for example, through being more addicted to smoking as well as being predisposed to schizophrenia. The discovered SNPs, combined with gene expression data, allowed the researchers to identify that lower brain expression of three genes neighboring the SNPs (involved in nicotine dependence) was causally linked to increased lifespan.
“Further analysis revealed that brain expression levels of nearby genes (RBM6, SULT1A1 and CHRNA5 ) might be causally implicated in longevity. Gene expression and caloric restriction experiments in model organisms confirm[1] the conserved role for RBM6 and SULT1A1 in modulating lifespan," the authors concluded.
“These three genes could, therefore, act as biomarkers of longevity, i.e., survival beyond 85 to 100 years,” commented study co-author Johan Auwerx, Ph.D., a professor at the EPFL. “To support this hypothesis, we have shown that mice with a lower brain expression level of RBM6 lived substantially longer.”
Study co-author Marc Robinson-Rechavi, Ph.D., a SIB group leader, and professor at the University of Lausanne, concluded that “interestingly, the gene expression impact of some of these SNPs in humans is analogous to the consequence of a low-calorie diet in mice, which is known to have positive effects on lifespan.” …” …More
Footnotes:
[1] “…Four among the down-regulated genes are involved in key regulatory steps within the pentose phosphate pathway, which has been previously associated with lifespan extension in Drosophila. Combined analysis of dietary switch with whole-genome time-course profiling can identify transcriptional responses that are closely associated with and perhaps causal to longevity assurance conferred by dietary restriction. …” - Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster