100% Bass-Ackwards

(Carolus Holman) #1

This article stinks of collusion with the Low Fat food industry!

#2

mice consuming a high-fat diet

Ok, stop right there folks. Hi fat mouse chow also has sucrose, maltodextrin and everything else they can find to make them fatter faster.

As for the amazing new discovery of GIP and the brain? Not really news. It’s GIP and GLP-1 that alter all kinds of hormonal responses to food, from pancreas to liver to brain.

P.S.
Guess what insulin does to GIP?

('Jackie P') #3

Just another load of mindless drivel☚

(Sheri Knauer) #4

Ugh. Rat chow. Plus they just say high fat, not high fat combined with high carbs and crappy oils will suppress leptin

(You've tried everything else; why not try bacon?) #5

But . . . but . . . but . . . sugar is natural, so it must be good for us.

NOT!

(Doug) #6

Exactly. If we’re going to research a “high-fat diet” then let’s actually do that, without all the confounding factors.

From the article: A high-fat diet has been linked with turning off the signal in the brain that indicates when you are full.

Well, it’s anecdotal in my case, but I also think it’s anecdotal for billions of people, worldwide - this is what eating a lot of carbohydrates does.

(Hyperbole- best thing in the universe!) #7

Right. As opposed to fat, which is entirely man-made. (Well, in the case of seed oils…)

(Dirty Lazy Keto'er, Sucralose freak ;)) #8

Mice might be a great test subject fort some biological tests, but they seem like a terrible choice for studies to do with human nutritional health. Come on, shouldn’t it be obvious that mice evolved completely differently than humans, when it comes to diet ???
This study sounds completely flawed, right from the start.

(Scott) #9

This is right up there when they compere a one diet with a keto diet where subjects “were on a keto diet for two weeks” and report they felt bad.

#10

Some things can be learned from mice, some things aren’t comparable. You certainly can’t dissect human brains and livers when your experiment ends either. But mouse study results should be a prelude to a study in humans that can verify results.

“Using cultured brain slices in petri dishes we screened blood circulating factors for their ability to stop leptin actions. After several years of efforts, we discovered a connection between the gut hormone GIP and leptin.”

In the case above, the leptin study was done in a lab petri dish, which is even further away from reality IRL. That’s why so many studies use the caveat “further testing is needed” in their conclusions. I didn’t bother googling the exact study they’re reporting in this case. It’s also been shown that certain fatty acids change satiety signals, but I bet they didn’t include those in the tests.

(Dirty Lazy Keto'er, Sucralose freak ;)) #11

Right ? …which would be like saying, "Patient felt bad after not using heroin for 2 weeks. Conclusion; Patient should continue using heroin. Wait, wtf ? :open_mouth:

(Parker the crazy crone lady) #12

I have to wonder what the food given to the mice contained in total.

#13

OK, I searched for the actual study, instead of just what the press release says, found the supplemental data, and here’s what the “high fat” diet looks like.

Research diet, D12492

This particular chow used both sucrose and Lodex 10, which is a proprietary maltodextrin. Maltodextrin is infamous for having a glycemic index above that of pure sugar. Just in case you’re wondering, the control diet is HERE (pdf).

Let’s not forget the role insulin plays in this. There’s more than just one factor altering hunger and satiety.

Taken together, these data provide in vivo evidence for a critical role of insulin signaling in catecholaminergic neurons to control food intake and energy homeostasis. (LINK)

(You've tried everything else; why not try bacon?) #14

Also, whenever I’ve looked up the diets mentioned in this type of study, the fat is either corn or soy oil. Never anything healthy.

#15

In this case, both groups were fed low levels of soybean oil, but the HF group had a boatload of added lard in addition to the insulinogenic sugar/carbs. The control group munched away on wheat and corn meal instead of fine granulated sucrose and maltodextrin. :face_vomiting:

(Jenny) #16

literally the exact opposite of what actually happens :joy:

(Margie) #17

Indeed sir!

(Jane) #18

Well, if the mice were fed a diet high in fat and sugar I would have to agree with the results. Who has ever (before keto) eaten a large dinner and were full but then a sugary cake or pie was set in front of them and suddenly there was room for it? Or easily eat a half dozen sugary doughnuts (1200 cal, 126 carbs, 66 g fat) and still not felt stuffed full?

(You've tried everything else; why not try bacon?) #19

Well, at least the fat was healthy, then.

I corresponded briefly with Peter at the Hyperlipid blog (he’s a vet) about getting rats into ketosis, and he said that it takes a diet that is almost exclusively of fat, and even then, you have to supplement with choline. Not practical (nor long-term healthy) for my babies, but good to know. I imagine it’s much the same with mice.

Apparently human beings are virtually unique in being able to slide in and out of ketosis so easily. Most other species find it much harder.